Periodontitis is a chronic inflammatory disease that affects tooth-supporting tissues and even
leads to tooth loss. NLRP3 inflammasomes play a critical role in periodontitis pathogenesis …

Periodontitis is a periodontal inflammatory condition that results from disrupted periodontal
host–microbe homeostasis, manifested by the destruction of tooth-supporting structures …

Objectives: To qualitatively and quantitatively review the use of melatonin as a
topical/systemic formulation for the management of periodontitis. Materials and methods …

Periodontitis as a highly prevalent chronic infection/inflammatory disease can eventually
lead to tooth loss and masticatory dysfunction. It also has a negative impact on general …

Objective This study aimed to evaluate the effect of adjunctive melatonin supplementation
on clinical outcomes after non-surgical periodontal treatment. Methods PubMed, Embase …

Featured Application Melatonin is a powerful antioxidant; it can bring numerous advantages
to periodontal diseases, pursuing homeostasis, such as restoration of the concentration of …

The role of nutrition in managing periodontal diseases is a dynamic and evolving area of
study. This review presents an in-depth analysis of various nutritional elements, including …

Inflammation-induced mitochondrial dysfunction functionally impairs periodontal ligament
stem cells (PDLSCs) and hinders their therapeutic efficacy in periodontal regeneration …

Objective To explore the potential targets for melatonin in the treatment of periodontitis
through network pharmacologic analysis and experimental validation via in vivo animal …

Inflammatory chemicals are released by the immune system in response to any perceived
danger, including irritants and pathogenic organisms. The caspase activation and the …