Visible-to-NIR-light activated release: from small molecules to nanomaterials

R Weinstain, T Slanina, D Kand, P Klan - Chemical reviews, 2020 - ACS Publications
Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable)
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …

Local translation in neurons: visualization and function

CE Holt, KC Martin, EM Schuman - Nature structural & molecular …, 2019 - nature.com
Neurons are among the most compartmentalized and interactive of all cell types. Like all
cells, neurons use proteins as the main sensors and effectors. The modification of the …

Mechanisms of drug release in nanotherapeutic delivery systems

PT Wong, SK Choi - Chemical reviews, 2015 - ACS Publications
Targeted drug delivery refers to an established therapeutic strategy that develops platforms
and nanoscale devices for selective delivery of small drug molecules and therapeutic genes …

mRNA transport & local translation in neurons

C Glock, M Heumüller, EM Schuman - Current opinion in neurobiology, 2017 - Elsevier
Highlights•∼ 2550 mRNA species are localized in dendrites and/or axons.•The alternative
usage of 3′ UTR isoforms dictates the fate of an mRNA molecule.•Novel multiplexed FISH …

Biologically active molecules with a “light switch”

G Mayer, A Heckel - Angewandte Chemie International Edition, 2006 - Wiley Online Library
Biologically active compounds which are light‐responsive offer experimental possibilities
which are otherwise very difficult to achieve. Since light can be manipulated very precisely …

Light-triggered release of photocaged therapeutics-Where are we now?

JM Silva, E Silva, RL Reis - Journal of Controlled Release, 2019 - Elsevier
The current available therapeutics face several challenges such as the development of ideal
drug delivery systems towards the goal of personalized treatments for patients benefit. The …

From one‐photon to two‐photon probes:“Caged” compounds, actuators, and photoswitches

G Bort, T Gallavardin, D Ogden… - Angewandte Chemie …, 2013 - Wiley Online Library
Molecular systems that can be remotely controlled by light are gaining increasing
importance in cell biology, physiology, and neurosciences because of the spatial and …

Dendrimer advances for the central nervous system delivery of therapeutics

L Xu, H Zhang, Y Wu - ACS chemical neuroscience, 2014 - ACS Publications
The effectiveness of noninvasive treatment for central nervous system (CNS) diseases is
generally limited by the poor access of therapeutic agents into the CNS. Most CNS drugs …

Photochemical control of biological processes

DD Young, A Deiters - Organic & biomolecular chemistry, 2007 - pubs.rsc.org
Photochemical regulation of biological processes offers a high level of control to study
intracellular mechanisms with unprecedented spatial and temporal resolution. This report …

Principles and applications of the photochemical control of cellular processes

A Deiters - Chembiochem: a European journal of chemical …, 2010 - pmc.ncbi.nlm.nih.gov
Biological processes, particularly gene function, are naturally regulated with high
spatiotemporal resolution in single cells and multicellular organisms. The activity of genes …