Although apoptosis, pyroptosis, and ferroptosis have been implicated in AD, none fully
explains the extensive neuronal loss observed in AD brains. Recent evidence shows that …

Neuronal death is one of the most common pathological hallmarks of diverse neurological
diseases, which manifest varying degrees of cognitive or motor dysfunction. Neuronal death …

Introduction Fasting glucose increases with age and is linked to modifiable Alzheimer's
disease risk factors such as cardiovascular disease and Type 2 diabetes (T2D). Methods We …

Abstract Background Granulovacuolar degeneration bodies (GVBs) are intracellular
vesicular structures that commonly accompany pathological tau accumulations in neurons of …

Understanding of central nervous system mechanisms underlying age-related infertility
remains limited. Fibril α-synuclein, distinct from its monomeric form, is implicated in age …

Extracellular β-amyloid (Aβ) deposition and intraneuronal phosphorylated-tau (pTau)
accumulation are the hallmark lesions of Alzheimer's disease (AD). Recently,“sorfra” …

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in
the axon. TAU is missorted and aggregated in an array of diseases known as tauopathies …

Background: There are few studies on the locus coeruleus (LC) in frontotemporal lobar
degeneration (FTLD) and the potential differences in the LC related to the underlying …

How neurons die in neurodegenerative diseases is still unknown. The distinction between
apoptosis as a genetically controlled mechanism, and necrosis, which was viewed as an …

Context: Understanding of central nervous system mechanisms related to age-related
infertility remains limited. Fibril α-synuclein, distinct from its monomer form, is implicated in …