T cell lineages are defined by specialized functions and differential expression of surface
antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T cells
through an 'inside out'signalling process whereby structurally diverse phosphoantigen (pAg) …

INTRODUCTION T cells represent a key component of the immune system that can
recognize foreign molecules (antigens) via cognate cell surface receptors termed T cell …

Summary Vγ9Vδ2 T cells respond in a TCR-dependent fashion to both microbial and host-
derived pyrophosphate compounds (phosphoantigens, or P-Ag). Butyrophilin-3A1 …

Vδ2+ T cells form the predominant human γδ T-cell population in peripheral blood and
mediate T-cell receptor (TCR)-dependent anti-microbial and anti-tumour immunity. Here we …

Butyrophilin (BTN) and butyrophilin-like (BTNL/Btnl) heteromers are major regulators of
human and mouse γδ T cell subsets, but considerable contention surrounds whether they …

The long-held view that gamma delta (γδ) T cells in mice and humans are fundamentally
dissimilar, as are γδ cells in blood and peripheral tissues, has been challenged by emerging …

Summary Vγ9Vδ2 T cells play critical roles in microbial immunity by detecting target cells
exposed to pathogen-derived phosphoantigens (P-Ags). Target cell expression of BTN3A1 …

Abstract γδ T cells are a small population of mostly tissue‐resident lymphocytes, with both
innate and adaptive properties. These unique features make them particularly attractive …