[HTML][HTML] Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers
The oral administration of therapeutic peptides and proteins is favoured from a patient and
commercial point of view. In order to reach the systemic circulation after oral administration …
commercial point of view. In order to reach the systemic circulation after oral administration …
The role of functional excipients in solid oral dosage forms to overcome poor drug dissolution and bioavailability
Many active pharmaceutical ingredients (APIs) exhibit poor solubility and low dissolution
rates in aqueous environments such as the luminal fluids of the gastrointestinal tract. The …
rates in aqueous environments such as the luminal fluids of the gastrointestinal tract. The …
Solid self emulsifying drug delivery system: Superior mode for oral delivery of hydrophobic cargos
I Maji, S Mahajan, A Sriram, P Medtiya… - Journal of Controlled …, 2021 - Elsevier
A significant proportion of recently approved drug molecules possess poor aqueous
solubility which further restrains their desired bioavailability. Poor aqueous solubility of these …
solubility which further restrains their desired bioavailability. Poor aqueous solubility of these …
Hot-melt extrusion: Highlighting recent advances in pharmaceutical applications
Hot-melt extrusion (HME) has emerged as a pioneering manufacturing technology for
pharmaceutical industries, and the utilization is overgrowing due to its unit operation, cost …
pharmaceutical industries, and the utilization is overgrowing due to its unit operation, cost …
[HTML][HTML] 3D-printing of solid lipid tablets from emulsion gels
Interest in 3D-printing technologies for pharmaceutical manufacturing of oral dosage forms
is driven by the need for personalized medicines. Most research to date has focused on …
is driven by the need for personalized medicines. Most research to date has focused on …
[HTML][HTML] Solubilization techniques used for poorly water-soluble drugs
B **e, Y Liu, X Li, P Yang, W He - Acta Pharmaceutica Sinica B, 2024 - Elsevier
Currently, about 40% of approved drugs and nearly 90% of drug candidates are poorly
water-soluble drugs. Low solubility reduces the likelihood that these drugs can be effectively …
water-soluble drugs. Low solubility reduces the likelihood that these drugs can be effectively …
[HTML][HTML] Synergistic stabilization of emulsion gel by nanoparticles and surfactant enables 3D printing of lipid-rich solid oral dosage forms
J Johannesson, MM Pathare, M Johansson… - Journal of Colloid and …, 2023 - Elsevier
Pharmaceutical formulation of oral dosage forms is continuously challenged by the low
solubility of new drug candidates. Pickering emulsions, emulsions stabilized with solid …
solubility of new drug candidates. Pickering emulsions, emulsions stabilized with solid …
[HTML][HTML] Battle of the milky way: Lymphatic targeted drug delivery for pathogen eradication
Many viruses, bacteria, and parasites rely on the lymphatic system for survival, replication,
and dissemination. While conventional anti-infectives can combat infection-causing agents …
and dissemination. While conventional anti-infectives can combat infection-causing agents …
[HTML][HTML] Self-emulsifying drug delivery systems (SEDDS) disrupt the gut microbiota and trigger an intestinal inflammatory response in rats
Self-emulsifying drug delivery systems (ie SEDDS, SMEDDS and SNEDDS) are widely
employed as solubility and bioavailability enhancing formulation strategies for poorly water …
employed as solubility and bioavailability enhancing formulation strategies for poorly water …
Self-emulsifying drug delivery system: Mucus permeation and innovative quantification technologies
Mucus is a dynamic barrier which covers and protects the underlying mucosal epithelial
membrane against bacteria and foreign particles. This protection mechanism extends to …
membrane against bacteria and foreign particles. This protection mechanism extends to …