Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique
morphological and functional properties that allow them to precisely control local circuitry …

Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …

The epidermal growth factor receptor (EGFR) is the prototypical member of a family of
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …

Background Depression is the most common mental illness. Mounting evidence suggests
that dysregulation of extracellular ATP (adenosine triphosphate) is involved in the …

Decreased serotonergic activity has been implicated in anxiety and major depression, and
antidepressants directly or indirectly increase the long-term activity of the serotonin system …

Abstract Background Patients with Alzheimer's disease (AD) are often co-morbid with
unprovoked seizures, making clinical diagnosis and management difficult. Although it has …

Acupuncture, as a traditional treatment, has been extensively used in China for thousands of
years. According to the World Health Organization (WHO), acupuncture is recommended for …

Abstract Neuregulin-1 (Nrg-1) is a member of the Neuregulin family of growth factors with
essential roles in the develo** and adult nervous system. Six different types of Nrg-1 (Nrg …

GABAergic interneurons play important roles in cortical circuit development. However, there
are multiple populations of interneurons and their respective developmental contributions …

A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to
multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and …