Plasmid DNA for therapeutic applications in cancer
Recently, the interest in using nucleic acids for therapeutic applications has been
increasing. DNA molecules can be manipulated to express a gene of interest for gene …
increasing. DNA molecules can be manipulated to express a gene of interest for gene …
MAGE-A3 immunotherapeutic as adjuvant therapy for patients with resected, MAGE-A3-positive, stage III melanoma (DERMA): a double-blind, randomised, placebo …
Background Despite newly approved treatments, metastatic melanoma remains a life-
threatening condition. We aimed to evaluate the efficacy of the MAGE-A3 …
threatening condition. We aimed to evaluate the efficacy of the MAGE-A3 …
Vaccination with human tyrosinase DNA induces antibody responses in dogs with advanced melanoma
JC F Liao, P Gregor, JD Wolchok, F Orlandi, D Craft… - Cancer immunity, 2006 - AACR
Antitumor immune responses can be elicited in preclinical mouse melanoma models using
plasmid DNA vaccines encoding xenogeneic melanosomal differentiation antigens. We …
plasmid DNA vaccines encoding xenogeneic melanosomal differentiation antigens. We …
Tumor stroma-associated antigens for anti-cancer immunotherapy
V Hofmeister, C Vetter, D Schrama, EB Bröcker… - Cancer Immunology …, 2006 - Springer
Immunotherapy has been widely investigated for its potential use in cancer therapy and it
becomes more and more apparent that the selection of target antigens is essential for its …
becomes more and more apparent that the selection of target antigens is essential for its …
The combination of stabilized plasmid lipid particles and lipid nanoparticle encapsulated CpG containing oligodeoxynucleotides as a systemic genetic vaccine
KD Wilson, SD de Jong, M Kazem… - The Journal of Gene …, 2009 - Wiley Online Library
Background DNA vaccines offer unique potential for generating protective and therapeutic
immunity against infectious and malignant diseases. Unfortunately, rapid degradation and …
immunity against infectious and malignant diseases. Unfortunately, rapid degradation and …
Treatment with an immature dendritic cell-targeting vaccine supplemented with IFN-α and an inhibitor of DNA methylation markedly enhances survival in a murine …
Background The chemokine MIP-3α (CCL20) binds to CCR6 on immature dendritic cells.
DNA vaccines fusing MIP-3α to melanoma-associated antigens have shown improved …
DNA vaccines fusing MIP-3α to melanoma-associated antigens have shown improved …
MUC1‐and Survivin‐based DNA Vaccine Combining Immunoadjuvants CpG and interleukin‐2 in a Bicistronic Expression Plasmid Generates Specific Immune …
C Liu, Y **e, B Sun, F Geng, F Zhang… - Scandinavian …, 2018 - Wiley Online Library
DNA vaccination is a promising cancer treatment due to its safety, but poor immunogenicity
limits its application. However, immunoadjuvants, heterogeneous prime‐boost strategies …
limits its application. However, immunoadjuvants, heterogeneous prime‐boost strategies …
Prostate stem cell antigen DNA vaccination breaks tolerance to self-antigen and inhibits prostate cancer growth
Prostate stem cell antigen (PSCA) is a cell surface antigen expressed in normal human
prostate and over expressed in prostate cancer. Elevated levels of PSCA protein in prostate …
prostate and over expressed in prostate cancer. Elevated levels of PSCA protein in prostate …
Immunological considerations underlying heat shock protein-mediated cancer vaccine strategies
M Kelly, D McNeel, P Fisch, M Malkovsky - Immunology Letters, 2018 - Elsevier
The success of active immunotherapies in the prevention of many infectious diseases over
the course of over 200 years has lead scientists to wonder if the same principles could be …
the course of over 200 years has lead scientists to wonder if the same principles could be …
Tumor chemo-immunotherapy using gemcitabine and a synthetic dsRNA
Both gemcitabine and synthetic double-stranded RNA (dsRNA) are known to be pro-
apoptotic and immuno-stimulatory (-modulatory). We sought to evaluate the extent to which …
apoptotic and immuno-stimulatory (-modulatory). We sought to evaluate the extent to which …