Abstract l-Arginine (Arg) is synthesised from glutamine, glutamate, and proline via the
intestinal-renal axis in humans and most other mammals (including pigs, sheep and rats) …

Mucosal repair is a complex event that immediately follows acute injury induced by ischemia
and noxious luminal contents such as bile. In the small intestine, villous contraction is the …

As a functional amino acid (AA), L-arginine (Arg) serves not only as a building block of
protein but also as an essential substrate for the synthesis of nitric oxide (NO), creatine …

The current climate changes have increased the prevalence and intensity of heat stress (HS)
conditions. One of the initial consequences of HS is the impairment of the intestinal epithelial …

Glutamine and leucine are abundant constituents of plant and animal proteins, whereas the
content of arginine in foods and physiological fluids varies greatly. Besides their role in …

Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality among infants
in the neonatal intensive care unit. Here we review the epidemiology and pathophysiology …

Arginine is a semi essential amino acid that is used in protein biosynthesis. It can be
obtained from daily food intake or synthesized in the body through the urea cycle using l …

The intestine is not only critical for the absorption of nutrients, but also interacts with a
complex external milieu. Most foreign antigens enter the body through the digestive tract …

Arginine deprivation is a novel antimetabolite strategy for the treatment of arginine-
dependent cancers that exploits differential expression and regulation of key urea cycle …

Mucosal surfaces are lined by epithelial cells and provide an important barrier to the flux of
antigens from the outside. This barrier is provided at a number of levels, including epithelial …