The role of BCL-2 family proteins in regulating apoptosis and cancer therapy

S Qian, Z Wei, W Yang, J Huang, Y Yang… - Frontiers in …, 2022 - frontiersin.org
Apoptosis, as a very important biological process, is a response to developmental cues or
cellular stress. Impaired apoptosis plays a central role in the development of cancer and …

[HTML][HTML] Biochemical features and therapeutic potential of α-Mangostin: Mechanism of action, medicinal values, and health benefits

M Alam, S Rashid, K Fatima, M Adnan, A Shafie… - Biomedicine & …, 2023 - Elsevier
Abstract α-Mangostin (α-MG) is a natural xanthone obtained from the pericarps of
mangosteen. It exhibits excellent potential, including anti-cancer, neuroprotective …

EGFR is a potential dual molecular target for cancer and Alzheimer's disease

HJ Choi, YJ Jeong, J Kim, HS Hoe - Frontiers in pharmacology, 2023 - frontiersin.org
Many researchers are attempting to identify drugs that can be repurposed as effective
therapies for Alzheimer's disease (AD). Several recent studies have highlighted epidermal …

Mechanisms of action of the BCL-2 inhibitor venetoclax in multiple myeloma: a literature review

Q Cao, X Wu, Q Zhang, J Gong, Y Chen… - Frontiers in …, 2023 - frontiersin.org
Abnormal cellular apoptosis plays a pivotal role in the pathogenesis of Multiple Myeloma
(MM). Over the years, BCL-2, a crucial anti-apoptotic protein, has garnered significant …

Current treatments for non-small cell lung cancer

Q Guo, L Liu, Z Chen, Y Fan, Y Zhou, Z Yuan… - Frontiers in …, 2022 - frontiersin.org
Despite improved methods of diagnosis and the development of different treatments,
mortality from lung cancer remains surprisingly high. Non-small cell lung cancer (NSCLC) …

[HTML][HTML] Investigating regulated signaling pathways in therapeutic targeting of non-small cell lung carcinoma

M Alam, GM Hasan, SM Eldin, M Adnan… - Biomedicine & …, 2023 - Elsevier
Non-small cell lung carcinoma (NSCLC) is the most common malignancy worldwide. The
signaling cascades are stimulated via genetic modifications in upstream signaling …

Therapeutic targeting of regulated signaling pathways of non-small cell lung carcinoma

GM Hasan, MI Hassan, SS Sohal, A Shamsi… - ACS omega, 2023 - ACS Publications
Non-small cell lung carcinoma (NSCLC) is the most common cancer globally.
Phytochemicals and small molecule inhibitors significantly prevent varying types of cancers …

Therapeutic implications and clinical manifestations of thymoquinone

M Alam, GM Hasan, MM Ansari, R Sharma, DK Yadav… - Phytochemistry, 2022 - Elsevier
Thymoquinone (TQ), a natural phytochemical predominantly found in Nigella sativa, has
been investigated for its numerous health benefits. TQ showed anti-cancer, anti-oxidant, and …

[HTML][HTML] Quercetin derivatives as potential therapeutic agents: an updated perspective on the treatment of nicotine-induced non-small cell lung cancer

NA Alsharairi - International Journal of Molecular Sciences, 2023 - mdpi.com
Flavonoids are the largest group of polyphenols, represented by many compounds that
exhibit high anticancer properties. Quercetin (Q) and its main derivatives (rutin, quercitrin …