Tumor glycolysis, an essential sweet tooth of tumor cells
Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …
Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism
I Elia, MC Haigis - Nature metabolism, 2021 - nature.com
Metabolic transformation is a hallmark of cancer and a critical target for cancer therapy.
Cancer metabolism and behaviour are regulated by cell-intrinsic factors as well as …
Cancer metabolism and behaviour are regulated by cell-intrinsic factors as well as …
[HTML][HTML] Glycogen accumulation and phase separation drives liver tumor initiation
Q Liu, J Li, W Zhang, C **ao, S Zhang, C Nian, J Li… - Cell, 2021 - cell.com
Glucose consumption is generally increased in tumor cells to support tumor growth.
Interestingly, we report that glycogen accumulation is a key initiating oncogenic event during …
Interestingly, we report that glycogen accumulation is a key initiating oncogenic event during …
Brain metastases
AS Achrol, RC Rennert, C Anders, R Soffietti… - Nature Reviews …, 2019 - nature.com
An estimated 20% of all patients with cancer will develop brain metastases, with the majority
of brain metastases occurring in those with lung, breast and colorectal cancers, melanoma …
of brain metastases occurring in those with lung, breast and colorectal cancers, melanoma …
Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity
Malignant brain tumours are complex ecosystems containing neoplastic and stromal
components that generate adaptive and evolutionarily driven aberrant tissues in the central …
components that generate adaptive and evolutionarily driven aberrant tissues in the central …
Brain metastasis
Brain metastasis, which commonly arises in patients with lung cancer, breast cancer and
melanoma, is associated with poor survival outcomes and poses distinct clinical challenges …
melanoma, is associated with poor survival outcomes and poses distinct clinical challenges …
Limited environmental serine and glycine confer brain metastasis sensitivity to PHGDH inhibition
A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic
constraints imposed by the serine and glycine–limited brain environment restrict metastatic …
constraints imposed by the serine and glycine–limited brain environment restrict metastatic …
Oxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers
R El-Botty, L Morriset, E Montaudon, Z Tariq… - Nature …, 2023 - nature.com
Resistance to endocrine treatments and CDK4/6 inhibitors is considered a near-inevitability
in most patients with estrogen receptor positive breast cancers (ER+ BC). By genomic and …
in most patients with estrogen receptor positive breast cancers (ER+ BC). By genomic and …
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
The development of life-threatening cancer metastases at distant organs requires
disseminated tumour cells' adaptation to, and co-evolution with, the drastically different …
disseminated tumour cells' adaptation to, and co-evolution with, the drastically different …
The metabolic mechanisms of breast cancer metastasis
L Wang, S Zhang, X Wang - Frontiers in Oncology, 2021 - frontiersin.org
Breast cancer is one of the most common malignancy among women worldwide. Metastasis
is mainly responsible for treatment failure and is the cause of most breast cancer deaths …
is mainly responsible for treatment failure and is the cause of most breast cancer deaths …