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[HTML][HTML] The GABAB Receptor—Structure, Ligand Binding and Drug Development
LSM Evenseth, M Gabrielsen, I Sylte - Molecules, 2020 - mdpi.com
The γ-aminobutyric acid (GABA) type B receptor (GABAB-R) belongs to class C of the G-
protein coupled receptors (GPCRs). Together with the GABAA receptor, the receptor …
protein coupled receptors (GPCRs). Together with the GABAA receptor, the receptor …
Classics in chemical neuroscience: baclofen
CN Kent, C Park, CW Lindsley - ACS chemical neuroscience, 2020 - ACS Publications
Baclofen, β-(4-chlorophenyl)-γ-aminobutyric acid, holds a unique position in neuroscience,
remaining the only US Food and Drug Administration (FDA) approved GABAB agonist …
remaining the only US Food and Drug Administration (FDA) approved GABAB agonist …
Highly stable Zr (IV)-based metal–organic frameworks for chiral separation in reversed-phase liquid chromatography
Separation of racemic mixtures is of great importance and interest in chemistry and
pharmacology. Porous materials including metal–organic frameworks (MOFs) have been …
pharmacology. Porous materials including metal–organic frameworks (MOFs) have been …
Ketamine treatment involves medial prefrontal cortex serotonin to induce a rapid antidepressant-like activity in BALB/cJ mice
Unlike classic serotonergic antidepressant drugs, ketamine, an NMDA receptor antagonist,
exhibits a rapid and persistent antidepressant (AD) activity, at sub-anaesthetic doses in …
exhibits a rapid and persistent antidepressant (AD) activity, at sub-anaesthetic doses in …
An update on the stereoselective synthesis of γ-amino acids
This review outlines the most recent papers describing the stereoselective synthesis of γ-
amino acids. In this update, the γ-amino acids have been classified according to the type of …
amino acids. In this update, the γ-amino acids have been classified according to the type of …
Enantioselective copper‐catalyzed radical ring‐opening cyanation of cyclopropanols and cyclopropanone acetals
L Wu, L Wang, P Chen, YL Guo… - Advanced Synthesis & …, 2020 - Wiley Online Library
A novel approach for enantioselective cyanation of cyclopropanols and their derivatives
through copper‐catalyzed radical relay processes has been developed. Various …
through copper‐catalyzed radical relay processes has been developed. Various …
Targets for drug therapy for autism spectrum disorder: challenges and future directions
E Lacivita, R Perrone, L Margari… - Journal of medicinal …, 2017 - ACS Publications
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by
persistent deficits in social communication and interaction and restricted, repetitive patterns …
persistent deficits in social communication and interaction and restricted, repetitive patterns …
Engineered MOFs and enzymes for the synthesis of active pharmaceutical ingredients
FG Cirujano - ChemCatChem, 2019 - Wiley Online Library
The latest strategies in the design and synthesis of metal‐organic frameworks as
heterogeneous catalysts in organic synthesis are compared with biocatalyzed …
heterogeneous catalysts in organic synthesis are compared with biocatalyzed …
Whole-Organism Transcriptomic Analysis Provides Mechanistic Insight into the Acute Toxicity of Emamectin Benzoate in Daphnia magna
Y Song, JT Rundberget, LM Evenseth… - Environmental …, 2016 - ACS Publications
Emamectin benzoate (EMB) is an antisea lice chemical widely used in the aquaculture that
may also unintentionally affect nontarget crustaceans in the environment. Although the …
may also unintentionally affect nontarget crustaceans in the environment. Although the …
Long-term results on the suppression of secondary brain injury by early administered low-dose baclofen in a traumatic brain injury mouse model
JY Park, J Park, J Baek, JW Chang, YG Kim… - Scientific reports, 2023 - nature.com
Secondary injury from traumatic brain injury (TBI) perpetuates cerebral damages through
varied ways. Attenuating neuroinflammation, which is a key feature of TBI, is important for …
varied ways. Attenuating neuroinflammation, which is a key feature of TBI, is important for …