Background When a patient arrives in the emergency department following a stroke, a
traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help …

Traumatic brain injury is a devastating, life-changing event in most cases. After the primary
brain insult, it is helpful to use evidence-based monitoring techniques to guide …

Background Within 2 min of severe ischemia, spreading depolarization (SD) propagates like
a wave through compromised gray matter of the higher brain. More SDs arise over hours in …

Despite changes in guideline-based management of moderate/severe traumatic brain injury
(TBI) over the preceding decades, little impact on mortality and morbidity have been seen …

Traumatic brain injuries cause enormous individual and socioeconomic burdens. Survivors
frequently struggle with motor handicaps as well as impaired cognition and emotion. In …

Drosophilae are emerging as a valuable model to study traumatic brain injury (TBI)-induced
secondary injury cascades that drive persisting neuroinflammation and neurodegenerative …

Poor outcomes in Subarachnoid Hemorrhage (SAH) are in part due to a unique form of
secondary neurological injury known as Delayed Cerebral Ischemia (DCI). DCI is …

Posttraumatic headache (PTH) attributed to traumatic brain injury (TBI) is a secondary
headache developed within 7 days after head injury, and in a substantial number of patients …

Traumatic subarachnoid hemorrhage (tSAH) is frequently comorbid with traumatic brain
injury (TBI) and may induce secondary injury through vascular changes such as vasospasm …

Cortical spreading depression (CSD) is an electrophysiologic pathological state in which a
wave of depolarization in the cerebral cortex is followed by the suppression of spontaneous …