The great plasticity of Schwann cells (SCs), the myelinating glia of the peripheral nervous
system (PNS), is a critical feature in the context of peripheral nerve regeneration following …

Schwann cells respond to nerve injury by cellular reprogramming that generates cells
specialized for promoting regeneration and repair. These repair cells clear redundant …

Mechanistic understanding of the topological cues delivered by biomaterials in promotion of
oriented tissue regeneration (eg., peripheral nerve regrowth) remains largely elusive. Here …

Electrical stimulation is a promising strategy for treating neural diseases. However, current
energy suppliers cannot provide effective power for in situ electrical stimulation. Here, an …

Traumatic peripheral nerve injury represents a major clinical and public health problem that
often leads to significant functional impairment and permanent disability. Despite modern …

Cell-type-specific gene expression is physiologically modulated by the binding of
transcription factors to genomic enhancer sequences, to which chromatin modifiers such as …

Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus that
affects approximately half of patients with diabetes. Current treatment regimens cannot treat …

Abstract Among different Histone deacetylases (HDACs), histone deacetylase 3 (HDAC3) is
an epigenetic drug target which is currently marked as a potential therapeutic strategy to …

Abstract Charcot‐Marie‐Tooth (CMT) neuropathies are one of the most common
neuromuscular disorders. However, despite the identification of more than 100 causative …

Platelets can secrete multiple growth factors for peripheral nerve repair. However, topically
injected platelets are rapidly activated followed by burst release of the cargos, causing …