Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities
C Lu, D Rong, B Zhang, W Zheng, X Wang, Z Chen… - Molecular cancer, 2019 - Springer
Incidence of hepatocellular carcinoma (HCC) is on the rise due to the prevalence of chronic
hepatitis and cirrhosis. Although there are surgical and chemotherapy treatment avenues …
hepatitis and cirrhosis. Although there are surgical and chemotherapy treatment avenues …
Lipid metabolism in cancer progression and therapeutic strategies
Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …
Eliminating METTL1‐mediated accumulation of PMN‐MDSCs prevents hepatocellular carcinoma recurrence after radiofrequency ablation
X Zeng, G Liao, S Li, H Liu, X Zhao, S Li, K Lei… - Hepatology, 2023 - journals.lww.com
Conclusions: Our study sheds light on the pivotal role of METTL1 in modulating an
immunosuppressive microenvironment and demonstrated that interrupting METTL1‐TGF‐β2 …
immunosuppressive microenvironment and demonstrated that interrupting METTL1‐TGF‐β2 …
Regulation and targeting of SREBP-1 in hepatocellular carcinoma
F Su, A Koeberle - Cancer and Metastasis Reviews, 2024 - Springer
Hepatocellular carcinoma (HCC) is an increasing burden on global public health and is
associated with enhanced lipogenesis, fatty acid uptake, and lipid metabolic …
associated with enhanced lipogenesis, fatty acid uptake, and lipid metabolic …
Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver
W Tang, J Zhou, W Yang, Y Feng, H Wu… - Cellular & Molecular …, 2022 - nature.com
Obesity is a major risk factor for cancers including hepatocellular carcinoma (HCC) that
develops from a background of non-alcoholic fatty liver disease (NAFLD) …
develops from a background of non-alcoholic fatty liver disease (NAFLD) …
Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and …
Background FOLFOX is a combinational regimen of folinic acid (FnA, FOL), fluorouracil (5-
Fu, F) and oxaliplatin (OxP, OX), and has been long considered as the standard treatment of …
Fu, F) and oxaliplatin (OxP, OX), and has been long considered as the standard treatment of …
Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment
L Yang, A Li, Q Lei, Y Zhang - Journal of hematology & oncology, 2019 - Springer
Immunotherapy is a currently popular treatment strategy for cancer patients. Although recent
developments in cancer immunotherapy have had significant clinical impact, only a subset …
developments in cancer immunotherapy have had significant clinical impact, only a subset …
The role and mechanism of oxidative stress and nuclear receptors in the development of NAFLD
T Hong, Y Chen, X Li, Y Lu - Oxidative medicine and cellular …, 2021 - Wiley Online Library
The overproduction of reactive oxygen species (ROS) and consequent oxidative stress
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …
Epidemiologic, genetic, pathogenic, metabolic, epigenetic aspects involved in NASH-HCC: current therapeutic strategies
J Gutiérrez-Cuevas, S Lucano-Landeros… - Cancers, 2022 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is an aggressive human cancer and is
caused as consequences of chronic liver diseases. Although HCC is more common in …
caused as consequences of chronic liver diseases. Although HCC is more common in …
Pathology and pathogenesis of metabolic dysfunction-associated steatotic liver disease-associated hepatic tumors
Y Takahashi, E Dungubat, H Kusano, T Fukusato - Biomedicines, 2023 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive fat accumulation in
the livers of patients without a history of alcohol abuse. It is classified as either simple …
the livers of patients without a history of alcohol abuse. It is classified as either simple …