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Systems biology in drug discovery
The hope of the rapid translation of'genes to drugs' has foundered on the reality that disease
biology is complex, and that drug development must be driven by insights into biological …
biology is complex, and that drug development must be driven by insights into biological …
A strategy for integrative computational physiology
Organ function (the heart beat for example) can only be understood through knowledge of
molecular and cellular processes within the constraints of structure-function relations at the …
molecular and cellular processes within the constraints of structure-function relations at the …
Computational methods for cardiac electromechanics
RCP Kerckhoffs, SN Healy, TP Usyk… - Proceedings of the …, 2006 - ieeexplore.ieee.org
Computational modeling provides a potentially powerful way to integrate structural
properties measured in vitro to physiological functions measured in vivo. Focusing on the …
properties measured in vitro to physiological functions measured in vivo. Focusing on the …
[کتاب][B] Advanced image processing in magnetic resonance imaging
L Landini, LT Mainardi, V Positano, AA Young… - 2018 - taylorfrancis.com
The popularity of magnetic resonance (MR) imaging in medicine is no mystery: it is non-
invasive, it produces high quality structural and functional image data, and it is very versatile …
invasive, it produces high quality structural and functional image data, and it is very versatile …
3D Imaging of vascular networks for biophysical modeling of perfusion distribution within the heart
One of the main determinants of perfusion distribution within an organ is the structure of its
vascular network. Past studies were based on angiography or corrosion casting and lacked …
vascular network. Past studies were based on angiography or corrosion casting and lacked …
Systems modeling: a pathway to drug discovery
Systems modeling is emerging as a valuable tool in therapeutics. This is seen by the
increasing use of clinically relevant computational models and a rise in systems biology …
increasing use of clinically relevant computational models and a rise in systems biology …
The significance of discovery screening and structure optimization studies
O Osakwe, SAA Rizvi - Social aspects of drug discovery …, 2016 - books.google.com
5.3. 2 Computer-Aided Drug Design 5.3. 3 Structure–Activity Relationship in Drug Discovery
5.3. 4 Pharmacophore Models of Drug Targeting 5.3. 5 Cheminformatics and Bioinformatics …
5.3. 4 Pharmacophore Models of Drug Targeting 5.3. 5 Cheminformatics and Bioinformatics …
[HTML][HTML] Modelling the cardiac transverse-axial tubular system
The transverse-axial tubular system (TATS) of cardiac ventricular myocytes is a complex
network of tubules that arises as invaginations of the surface membrane; it appears to form a …
network of tubules that arises as invaginations of the surface membrane; it appears to form a …
Strategies and tactics in multiscale modeling of cell-to-organ systems
Modeling is essential to integrating knowledge of human physiology. Comprehensive self-
consistent descriptions expressed in quantitative mathematical form define working …
consistent descriptions expressed in quantitative mathematical form define working …
Modeling human physiology: The IUPS/EMBS physiome project
The Physiome Project is an international collaboration to provide a framework for
understanding human physiology, from proteins and cells to tissues and organs, with …
understanding human physiology, from proteins and cells to tissues and organs, with …