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Drug repurposing for cancer therapy
Y ** foundation models for …
Current progress and open challenges for applying deep learning across the biosciences
Deep Learning (DL) has recently enabled unprecedented advances in one of the grand
challenges in computational biology: the half-century-old problem of protein structure …
challenges in computational biology: the half-century-old problem of protein structure …
[HTML][HTML] Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer
In contrast to normal type I collagen (Col1) heterotrimer (α1/α2/α1) produced by fibroblasts,
pancreatic cancer cells specifically produce unique Col1 homotrimer (α1/α1/α1). Col1 …
pancreatic cancer cells specifically produce unique Col1 homotrimer (α1/α1/α1). Col1 …
Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins
K Pance, JA Gramespacher, JR Byrnes… - Nature …, 2023 - nature.com
Targeted degradation of cell surface and extracellular proteins via lysosomal delivery is an
important means to modulate extracellular biology. However, these approaches have …
important means to modulate extracellular biology. However, these approaches have …
Next-generation cancer organoids
Organotypic models of patient-specific tumours are revolutionizing our understanding of
cancer heterogeneity and its implications for personalized medicine. These advancements …
cancer heterogeneity and its implications for personalized medicine. These advancements …
Understanding and overcoming resistance to PARP inhibitors in cancer therapy
Develo** novel targeted anticancer therapies is a major goal of current research. The use
of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with homologous …
of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with homologous …
Artificial intelligence in cancer research and precision medicine
Artificial intelligence (AI) is rapidly resha** cancer research and personalized clinical
care. Availability of high-dimensionality datasets coupled with advances in high …
care. Availability of high-dimensionality datasets coupled with advances in high …
Oncogene-like addiction to aneuploidy in human cancers
Most cancers exhibit aneuploidy, but its functional significance in tumor development is
controversial. Here, we describe ReDACT (Restoring Disomy in Aneuploid cells using …
controversial. Here, we describe ReDACT (Restoring Disomy in Aneuploid cells using …