The endothelium is considered to be the gatekeeper of the vessel wall, maintaining and
regulating vascular integrity. In patients with chronic kidney disease, protective endothelial …

The kidney harbours different types of endothelia, each with specific structural and functional
characteristics. The glomerular endothelium, which is highly fenestrated and covered by a …

Endothelial dysfunction is one of the earliest indicators of cardiovascular (CV) dysfunction,
and its evaluation would be of considerable importance to stratify CV risk of many diseases …

The prevalence of chronic kidney disease (CKD) is increasing worldwide, and the mortality
rate continues to be unacceptably high. The biomarkers currently used in clinical practice …

Chronic kidney disease (CKD) is one of the major health problems of the modern age. It
represents an important public health challenge with an ever-lasting rising prevalence …

Collagen XVIII is a ubiquitous basement membrane (BM) proteoglycan produced in three
tissue-specific isoforms that differ in their N-terminal non-collagenous sequences, but share …

Chronic kidney disease (CKD) patients have an accelerated atherosclerosis, increased risk
of thrombotic-ischemic complications, and excessive mortality rates when compared with the …

Lung fibrosis is characterized by excessive deposition of extracellular matrix (ECM), in
particular collagens, by fibroblasts in the interstitium. Transforming growth factor-β1 (TGF …

Uremic toxins can induce endothelial dysfunction in patients with chronic kidney disease
(CKD). Indeed, the structure of the endothelial monolayer is damaged in CKD, and studies …

Introduction Patients with chronic kidney disease (CKD) have a high risk of death mainly due
to cardiovascular diseases (CVD). Early risk identification may allow interventions and …