Post-translational modifications (PTMs) endow proteins with new properties to respond to
environmental changes or growth needs. With the development of advanced proteomics …

Nature has produced intricate machinery to covalently diversify the structure of proteins after
their synthesis in the ribosome. In an attempt to mimic nature, chemists have developed a …

Heterochromatin affects genome function at many levels. It enables heritable gene
repression, maintains chromosome integrity and provides mechanical rigidity to the …

Eukaryotic chromosomes contain compartments of various functions, which are marked by
and enriched with specific histone modifications. However, the molecular mechanisms by …

Pioneer transcription factors have the ability to access DNA in compacted chromatin.
Multiple transcription factors can bind together to a regulatory element in a cooperative way …

Mammalian development requires effective mechanisms to repress genes whose
expression would generate inappropriately specified cells. The Polycomb-repressive …

INTRODUCTION Histone modification activity of the polycomb repressive complexes 1 and
2 (PRC1 and PRC2) is critical for the establishment and maintenance of gene expression …

Post-translational modifications (PTMs) dynamically regulate cellular processes. Lysine
undergoes a range of acylations, including malonylation, succinylation (SucK) and …

Bioconjugation methodologies have proven to play a central enabling role in the recent
development of biotherapeutics and chemical biology approaches. Recent endeavours in …

In living systems, the chemical space and functional repertoire of proteins are dramatically
expanded through the post-translational modification (PTM) of various amino acid residues …