The pancreatic duodenum homeobox-1 (PDX-1) is a transcription factor encoded by a Hox-
like homeodomain gene that plays a crucial role in pancreatic development, β-cell …

The pancreas is a mixed exocrine and endocrine gland that controls many homeostatic
functions. The exocrine pancreas produces and secretes digestive enzymes, whereas the …

To study the late β-cell-specific function of the homeodomain protein IPF1/PDX1 we have
generated mice in which the Ipf1/Pdx1 gene has been disrupted specifically in β cells. These …

Insulin gene expression is restricted to islet β cells of the mammalian pancreas through
specific control mechanisms mediated in part by specific transcription factors 1, 2. The …

Differentiated pancreatic β cells are unique in their ability to secrete insulin in response to a
rise in plasma glucose. We have proposed that the unique constellation of genes they …

The endocrine cells of the rat pancreatic islets of Langerhans, including insulin-producing β-
cells, turn over every 40–50 days by processes of apoptosis and the proliferation and …

The endocrine pancreas is organized into clusters of cells called islets of Langerhans
comprising four well-defined cell types: α, β, δ and PP cells. While recent genetic studies …

MafA is a transcription factor that binds to the promoter in the insulin gene and has been
postulated to regulate insulin transcription in response to serum glucose levels, but there is …

We show that transplantation of adult bone marrow–derived cells expressing c-kit reduces
hyperglycemia in mice with streptozotocin-induced pancreatic damage. Although …

Most insulin-producing β-cells in the fetal mouse pancreas arise during the secondary
transition, a wave of differentiation starting at embryonic day 13. Here, we show that …