Ever since microRNAs (miRNAs) were first recognized as an extensive gene family> 20
years ago, a broad community of researchers was drawn to investigate the universe of small …

MicroRNAs (miRNAs) are versatile, post-transcriptional regulators of gene expression.
Canonical miRNAs are generated through the two-step DROSHA-and DICER-mediated …

Up to 80% of the human genome produces “dark matter” RNAs, most of which are
noncapped RNAs (napRNAs) that frequently act as noncoding RNAs (ncRNAs) to modulate …

The ability to interrogate total RNA content of single cells would enable better map** of
the transcriptional logic behind emerging cell types and states. However, current single-cell …

In mammalian cells, primary miRNAs are cleaved at their hairpin structures by the
Microprocessor complex, whose core is composed of DROSHA and DGCR8. Here, we show …

An important proportion of microRNA (miRNA) genes tend to lie close to each other within
animal genomes. Such genomic organization is generally referred to as miRNA clusters …

Nuclear processing of most miRNAs is mediated by Microprocessor, comprised of RNase III
enzyme Drosha and its cofactor DGCR8. Here, we uncover a hidden layer of Microprocessor …

Long noncoding RNAs (lncRNAs) can drive tumorigenesis and are susceptible to
therapeutic intervention. Here, we used a large-scale CRISPR interference viability screen …

MicroRNAs are prevalent regulators of gene expression, controlling most of the proteome in
multicellular organisms. To generate the functional small RNAs, precise processing steps …

MicroRNAs (miRNAs) are non-coding RNAs which modulate gene expression via multiple
post-transcriptional mechanisms. They are involved in a variety of biological processes …