Protein–RNA interactions have crucial roles in various cellular activities, which, when
dysregulated, can lead to a range of human diseases. The identification of small molecules …

Highlights•RNA-binding proteins (RBPs) are essential for tumorigenesis, immune evasion,
invasion, migration and metastasis, hence promising drug targets in cancer therapy.•Small …

Acquired immunodeficiency syndrome (AIDS) is an enormous global health threat stemming
from human immunodeficiency virus (HIV-1) infection. Up to now, the tremendous advances …

The HIV genome encodes a small number of viral proteins (ie, 16), invariably establishing
cooperative associations among HIV proteins and between HIV and host proteins, to invade …

RNA‐binding proteins (RBPs) play vital roles in organisms through binding with RNAs to
regulate their functions. Small molecules affecting the function of RBPs have been …

The matrix (MA) domains of HIV-1 precursor Gag (PrGag) proteins direct PrGag proteins to
plasma membrane (PM) assembly sites where envelope (Env) protein trimers are …

The highly virulent nature of Ebola virus, evident from the 2014 West African pandemic,
highlights the need to develop vaccines or therapeutic agents that limit the pathogenesis …

We have examined the interactions of wild-type (WT) and matrix protein-deleted (ΔMA) HIV-
1 precursor Gag (PrGag) proteins in virus-producing cells using a biotin ligase-tagging …

Background HIV-1 replication can be successfully blocked by targeting gag gene products,
offering a promising strategy for new drug classes that complement current HIV-1 treatment …

RNA-binding proteins (RBPs) are pleiotropic factors that control the processing and
functional compartmentalization of transcripts by binding primarily to mRNA untranslated …