Lactate metabolism in human health and disease

X Li, Y Yang, B Zhang, X Lin, X Fu, Y An… - Signal transduction and …, 2022 - nature.com
The current understanding of lactate extends from its origins as a byproduct of glycolysis to
its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate …

Recent developments in enzymatic antioxidant defence mechanism in plants with special reference to abiotic stress

VD Rajput, Harish, RK Singh, KK Verma, L Sharma… - Biology, 2021 - mdpi.com
Simple Summary Higher plants face a variety of stress conditions. There are a number of
different antioxidant enzymes that help plants to cope with these stresses. During stresses …

[HTML][HTML] ROS and the DNA damage response in cancer

US Srinivas, BWQ Tan, BA Vellayappan… - Redox biology, 2019 - Elsevier
Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-
containing molecules that can induce DNA damage and affect the DNA damage response …

Plants facing oxidative challenges—A little help from the antioxidant networks

C Soares, MEA Carvalho, RA Azevedo… - … and Experimental Botany, 2019 - Elsevier
A large number of reviews have discussed many aspects of oxidative burst due to plant
exposure to biotic and abiotic stresses, including the dual role of reactive oxygen species …

Copper active sites in biology

EI Solomon, DE Heppner, EM Johnston… - Chemical …, 2014 - ACS Publications
On the basis of its generally accessible I/II redox couple and bioavailability, copper plays a
wide variety of roles in nature that mostly involve electron transfer (ET), O 2 binding …

Superoxide dismutases and superoxide reductases

Y Sheng, IA Abreu, DE Cabelli, MJ Maroney… - Chemical …, 2014 - ACS Publications
Superoxide, O2•−, is formed in all living organisms that come in contact with air, and,
depending upon its biological context, it may act as a signaling agent, a toxic species, or a …

Timing the evolution of antioxidant enzymes in cyanobacteria

JS Boden, KO Konhauser, LJ Robbins… - Nature …, 2021 - nature.com
The ancestors of cyanobacteria generated Earth's first biogenic molecular oxygen, but how
they dealt with oxidative stress remains unconstrained. Here we investigate when …

Metabolism and functions of copper in brain

IF Scheiber, JFB Mercer, R Dringen - Progress in neurobiology, 2014 - Elsevier
Copper is an important trace element that is required for essential enzymes. However, due
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …

[HTML][HTML] An insight on superoxide dismutase (SOD) from plants for mammalian health enhancement

S Stephenie, YP Chang, A Gnanasekaran… - Journal of Functional …, 2020 - Elsevier
Superoxide dismutase (SOD) is an antioxidant enzyme functional for physiological defense
strategies in animals and plants against free radicals and reactive oxygen species (ROS) …

Reactive oxygen species in chronic obstructive pulmonary disease

S Boukhenouna, MA Wilson, K Bahmed… - Oxidative medicine …, 2018 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) includes chronic bronchitis and
emphysema. Environmental exposure, primarily cigarette smoking, can cause high oxidative …