An update of epigenetic drugs for the treatment of cancers and brain diseases: a comprehensive review
Epigenetics has long been recognized as a significant field in biology and is defined as the
investigation of any alteration in gene expression patterns that is not attributed to changes in …
investigation of any alteration in gene expression patterns that is not attributed to changes in …
Epigenetics and microRNAs in cancer
The ability to reprogram the transcriptional circuitry by remodeling the three-dimensional
structure of the genome is exploited by cancer cells to promote tumorigenesis. This …
structure of the genome is exploited by cancer cells to promote tumorigenesis. This …
Dual role of microRNA-31 in human cancers; focusing on cancer pathogenesis and signaling pathways
Widespread changes in the expression of microRNAs in cancer result in abnormal gene
expression for the miRNAs that control those genes, which in turn causes changes to entire …
expression for the miRNAs that control those genes, which in turn causes changes to entire …
Taxanes loaded polymersomes as an emerging polymeric nanocarrier for cancer therapy
Cancer has since long remained a cause of concern which has eventually become leading
cause of mortality. It was in the late 90 s, when polymersomes were identified as a platform …
cause of mortality. It was in the late 90 s, when polymersomes were identified as a platform …
Histone deacetylase inhibitors and phenotypical transformation of cancer cells
A Wawruszak, J Kalafut, E Okon, J Czapinski, M Halasa… - Cancers, 2019 - mdpi.com
Histone deacetylase inhibitors (HDIs) are a group of potent epigenetic drugs which have
been investigated for their therapeutic potential in various clinical disorders, including …
been investigated for their therapeutic potential in various clinical disorders, including …
Histone deacetylases as new therapeutic targets in triple-negative breast cancer: Progress and promises
N Garmpis, C Damaskos, A Garmpi… - Cancer Genomics & …, 2017 - cgp.iiarjournals.org
Triple-negative breast cancer (TNBC) lacks expression of estrogen receptor (ER),
progesterone receptor (PR) and HER2 gene. It comprises approximately 15-20% of breast …
progesterone receptor (PR) and HER2 gene. It comprises approximately 15-20% of breast …
Genome‐Wide CRISPR‐Cas9 Screening Identifies NF‐κB/E2F6 Responsible for EGFRvIII‐Associated Temozolomide Resistance in Glioblastoma
K Huang, X Liu, Y Li, Q Wang, J Zhou… - Advanced …, 2019 - Wiley Online Library
Amplification of epidermal growth factor receptor (EGFR) and active mutant EGFRvIII occurs
frequently in glioblastoma (GBM) and contributes to chemo/radio‐resistance in various …
frequently in glioblastoma (GBM) and contributes to chemo/radio‐resistance in various …
Epigenetic mechanisms in DNA double strand break repair: A clinical review
Upon the induction of DNA damage, the chromatin structure unwinds to allow access to
enzymes to catalyse the repair. The regulation of the winding and unwinding of chromatin …
enzymes to catalyse the repair. The regulation of the winding and unwinding of chromatin …
Pulmonary function and blood DNA methylation: a multiancestry epigenome-wide association meta-analysis
Rationale: Methylation integrates factors present at birth and modifiable across the lifespan
that can influence pulmonary function. Studies are limited in scope and replication …
that can influence pulmonary function. Studies are limited in scope and replication …
Targeted nanomedicine modalities for prostate cancer treatment
Prostate cancer (PC) is the second most common cause of death amongst men in the USA.
Therapy of PC has been transformed in the past decade by introducing novel therapeutics …
Therapy of PC has been transformed in the past decade by introducing novel therapeutics …