Metal complexes in cancer therapy–an update from drug design perspective
In the past, metal-based compounds were widely used in the treatment of disease
conditions, but the lack of clear distinction between the therapeutic and toxic doses was a …
conditions, but the lack of clear distinction between the therapeutic and toxic doses was a …
The involvement of the oxidative stress status in cancer pathology: a double view on the role of the antioxidants
Oxygen‐free radicals, reactive oxygen species (ROS) or reactive nitrogen species (RNS),
are known by their “double‐sided” nature in biological systems. The beneficial effects of …
are known by their “double‐sided” nature in biological systems. The beneficial effects of …
Recent development of copper (II) complexes of polypyridyl ligands in chemotherapy and photodynamic therapy
Cancer is a deadly disease associated with abnormal cell growth and invasion to various
parts of the body. Many drugs such as cisplatin and carboplatin have been used for the …
parts of the body. Many drugs such as cisplatin and carboplatin have been used for the …
Synthesis, DNA binding and antibacterial activity of metal (II) complexes of a benzimidazole Schiff base
Abstract The benzimidazole derivative (E)-2-((4-(1H-benzo [d] imidazol-2-yl) phenylimino)
methyl)-4-bromo phenol and the corresponding Zn (II), Ni (II), Cu (II), and Pd (II) complexes …
methyl)-4-bromo phenol and the corresponding Zn (II), Ni (II), Cu (II), and Pd (II) complexes …
[HTML][HTML] Copper homeostasis and copper-induced cell death: novel targeting for intervention in the pathogenesis of vascular aging
Z Chen, Y Li, X Liu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Copper-induced cell death, also known as cuproptosis, is distinct from other types of cell
death such as apoptosis, necrosis, and ferroptosis. It can trigger the accumulation of lethal …
death such as apoptosis, necrosis, and ferroptosis. It can trigger the accumulation of lethal …
Redox-implications associated with the formation of complexes between copper ions and reduced or oxidized glutathione
ME Aliaga, C López-Alarcón, R Bridi… - Journal of inorganic …, 2016 - Elsevier
Binding of copper by reduced glutathione (GSH) is generally seen as a mechanism to lower,
if not abolish, the otherwise high electrophilicity and redox activity of its free ions. In recent …
if not abolish, the otherwise high electrophilicity and redox activity of its free ions. In recent …
Metal complexes of benzimidazole derived sulfonamide: Synthesis, molecular structures and antimicrobial activity
Benzimidazole and sulfonamide moieties are found in a number of pharmaceutically active
molecules. By incorporating the sulfonamide pharmacophore into the benzimidazole …
molecules. By incorporating the sulfonamide pharmacophore into the benzimidazole …
Synthesis, characterization, molecular docking and antimicrobial activity of copper (II) complexes of metronidazole and 1, 10 phenanthroline
Three new compounds containing mono-and dinuclear Cu (II) complexes,[Cu (Met) 2 Cl 2] 2,
Cu (H 2 O)(Met) 2 Cl] 2 and [Cu (H 2 O)(phen) 2] NO 3 (Met= metronidazole; Phen= 1, 10 …
Cu (H 2 O)(Met) 2 Cl] 2 and [Cu (H 2 O)(phen) 2] NO 3 (Met= metronidazole; Phen= 1, 10 …
Emerging Trends in Metal‐based Anticancer Agents: Drug Design to Clinical Trials and their Mechanism of Action
A Temesgen, HC Ananda Murthy, AZ Enyew… - …, 2023 - Wiley Online Library
Metal‐based therapeutic strategies have been effectively used to treat a number of diseases
since the ancient period. However, the issue that emerged at this time was the indistinct …
since the ancient period. However, the issue that emerged at this time was the indistinct …
An insight into the cytotoxic, antimicrobial, antioxidant, and biocontrol perspective of novel Iron (III) complexes of substituted benzimidazoles: Inhibition kinetics and …
Abstract Mononuclear complexes [FeCl3L2 (OH2)](L= L1, L2) were designed and
synthesized by combining FeCl3 with 2-(3′-Aminophenylbenzimidazole)(L1) and 2-[(3′-N …
synthesized by combining FeCl3 with 2-(3′-Aminophenylbenzimidazole)(L1) and 2-[(3′-N …