The importance of antimicrobial resistance in medical mycology

NAR Gow, C Johnson, J Berman, AT Coste… - Nature …, 2022 - nature.com
Prior to the SARS-CoV-2 pandemic, antibiotic resistance was listed as the major global
health care priority. Some analyses, including the O'Neill report, have predicted that deaths …

Drug-resistant fungi: an emerging challenge threatening our limited antifungal armamentarium

A Arastehfar, T Gabaldón, R Garcia-Rubio, JD Jenks… - Antibiotics, 2020 - mdpi.com
The high clinical mortality and economic burden posed by invasive fungal infections (IFIs),
along with significant agricultural crop loss caused by various fungal species, has resulted in …

VEuPathDB: the eukaryotic pathogen, vector and host bioinformatics resource center

B Amos, C Aurrecoechea, M Barba… - Nucleic acids …, 2022 - academic.oup.com
Abstract The Eukaryotic Pathogen, Vector and Host Informatics Resource (VEuPathDB,
https://veupathdb. org) represents the 2019 merger of VectorBase with the EuPathDB …

Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment

J Rhodes, A Abdolrasouli, K Dunne, TR Sewell… - Nature …, 2022 - nature.com
Infections caused by the fungal pathogen Aspergillus fumigatus are increasingly resistant to
first-line azole antifungal drugs. However, despite its clinical importance, little is known …

A molecular vision of fungal cell wall organization by functional genomics and solid-state NMR

A Chakraborty, LD Fernando, W Fang… - Nature …, 2021 - nature.com
Vast efforts have been devoted to the development of antifungal drugs targeting the cell wall,
but the supramolecular architecture of this carbohydrate-rich composite remains …

Flucytosine and its clinical usage

LSM Sigera, DW Denning - Therapeutic advances in …, 2023 - journals.sagepub.com
Flucytosine is an antifungal agent first licensed in the 1970's. However, its clinical value has
long been overlooked and its availability across the globe is limited. This review highlights …

Molecular mechanisms of acquired antifungal drug resistance in principal fungal pathogens and EUCAST guidance for their laboratory detection and clinical …

TR Rogers, PE Verweij, M Castanheira… - Journal of …, 2022 - academic.oup.com
The increasing incidence and changing epidemiology of invasive fungal infections continue
to present many challenges to their effective management. The repertoire of antifungal drugs …

[HTML][HTML] The consequences of our changing environment on life threatening and debilitating fungal diseases in humans

N Van Rhijn, M Bromley - Journal of Fungi, 2021 - mdpi.com
Human activities have significantly impacted the environment and are changing our climate
in ways that will have major consequences for ourselves, and endanger animal, plant and …

Aspergillus fumigatus and aspergillosis: from basics to clinics

A Arastehfar, A Carvalho, J Houbraken… - Studies in …, 2021 - ingentaconnect.com
The airborne fungus Aspergillus fumigatus poses a serious health threat to humans by
causing numerous invasive infections and a notable mortality in humans, especially in …

What is new in FungiDB: a web-based bioinformatics platform for omics-scale data analysis for fungal and oomycete species

EY Basenko, A Shanmugasundram, U Böhme… - Genetics, 2024 - academic.oup.com
Abstract FungiDB (https://fungidb. org) serves as a valuable online resource that seamlessly
integrates genomic and related large-scale data for a wide range of fungal and oomycete …