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NTRK fusion-positive cancers and TRK inhibitor therapy
N TRK gene fusions involving either NTRK1, NTRK2 or NTRK3 (encoding the neurotrophin
receptors TRKA, TRKB and TRKC, respectively) are oncogenic drivers of various adult and …
receptors TRKA, TRKB and TRKC, respectively) are oncogenic drivers of various adult and …
The sympathetic nervous system in development and disease
The sympathetic nervous system prepares the body for 'fight or flight'responses and
maintains homeostasis during daily activities such as exercise, eating a meal or regulation …
maintains homeostasis during daily activities such as exercise, eating a meal or regulation …
Nerve growth factor signaling and its contribution to pain
Nerve growth factor (NGF) is a neurotrophic protein essential for the growth, differentiation,
and survival of sympathetic and sensory afferent neurons during development. A substantial …
and survival of sympathetic and sensory afferent neurons during development. A substantial …
[HTML][HTML] Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer
The tropomyosin receptor kinase (TRK) family of receptor tyrosine kinases are encoded by
NTRK genes and have a role in the development and normal functioning of the nervous …
NTRK genes and have a role in the development and normal functioning of the nervous …
[HTML][HTML] TRK inhibitors in TRK fusion-positive cancers
TRK fusions are oncogenic drivers of various adult and paediatric cancers. The first-
generation TRK inhibitors, larotrectinib and entrectinib, were granted landmark, tumour …
generation TRK inhibitors, larotrectinib and entrectinib, were granted landmark, tumour …
TRKing down an old oncogene in a new era of targeted therapy
The use of high-throughput next-generation sequencing techniques in multiple tumor types
during the last few years has identified NTRK1, 2, and 3 gene rearrangements encoding …
during the last few years has identified NTRK1, 2, and 3 gene rearrangements encoding …
GDNF, NGF and BDNF as therapeutic options for neurodegeneration
Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor
(NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival …
(NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival …
The cellular and molecular basis of somatosensory neuron development
Primary somatosensory neurons convey salient information about our external environment
and internal state to the CNS, allowing us to detect, perceive, and react to a wide range of …
and internal state to the CNS, allowing us to detect, perceive, and react to a wide range of …
Neurotrophins: roles in neuronal development and function
▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …
The induction of pain: an integrative review
MJ Millan - Progress in neurobiology, 1999 - Elsevier
The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …