Acute respiratory distress syndrome (ARDS) is the often fatal sequelae of a broad range of
precipitating conditions. Despite decades of intensive research and clinical trials there …

In many respiratory diseases characterized by an intense inflammatory response, the
balance between proteolytic enzymes (proteases, including elastases) and their inhibitors …

Graft-versus-host disease (GVHD), the major complication of allogeneic bone marrow
transplantation, affects the skin, liver, and gastrointestinal tract. There are no plasma …

Neutrophils are polymorphonuclear leukocytes that play a central role in host defense
against infection and tissue injury. They are rapidly recruited to the inflamed site and …

Background & Aims Colonic tissues of patients with inflammatory bowel disease have been
reported to have increased proteolytic activity, but no studies have clearly addressed the …

Neutrophil serine proteases: mediators of innate immune resp... : Current Opinion in
Hematology Neutrophil serine proteases: mediators of innate immune responses : Current …

Elafin and secretory leukocyte protease inhibitor (SLPI) are pleiotropic molecules chiefly
synthesized at the mucosal surface that have a fundamental role in the surveillance against …

Introduction: Human neutrophil elastase (HNE) is involved in a variety of serious chronic
diseases, especially cardiopulmonary pathologies. For this reason, the regulation of HNE …

Marine organisms are rich sources of enzymes and their inhibitors having enormous
therapeutic potential. Among different proteolytic enzymes, serine proteases, which can be …

Chronic obstructive pulmonary disease (COPD) is a major increasing health problem and
the World Health Organization (WHO) reports COPD as the fifth leading cause of death …