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Creatine in health and disease
Although creatine has been mostly studied as an ergogenic aid for exercise, training, and
sport, several health and potential therapeutic benefits have been reported. This is because …
sport, several health and potential therapeutic benefits have been reported. This is because …
Spinocerebellar ataxia
The spinocerebellar ataxias (SCAs) are a genetically heterogeneous group of autosomal
dominantly inherited progressive disorders, the clinical hallmark of which is loss of balance …
dominantly inherited progressive disorders, the clinical hallmark of which is loss of balance …
Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of spinocerebellar ataxia type 3
Spinocerebellar ataxia type 3 (SCA3) is an adult-onset neurodegenerative disease caused
by a polyglutamine expansion in the ataxin-3 (ATXN3) gene. No effective treatment is …
by a polyglutamine expansion in the ataxin-3 (ATXN3) gene. No effective treatment is …
Machado–Joseph disease/spinocerebellar ataxia type 3: lessons from disease pathogenesis and clues into therapy
Abstract Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3
(SCA 3), is an incurable disorder, widely regarded as the most common form of …
(SCA 3), is an incurable disorder, widely regarded as the most common form of …
Mitochondrial function and dynamics in neural stem cells and neurogenesis: Implications for neurodegenerative diseases
P Coelho, L Fão, S Mota, AC Rego - Ageing research reviews, 2022 - Elsevier
Mitochondria have been largely described as the powerhouse of the cell and recent findings
demonstrate that this organelle is fundamental for neurogenesis. The mechanisms …
demonstrate that this organelle is fundamental for neurogenesis. The mechanisms …
Aberrant cerebellar circuitry in the spinocerebellar ataxias
The spinocerebellar ataxias (SCAs) are a heterogeneous group of neurodegenerative
diseases that share convergent disease features. A common symptom of these diseases is …
diseases that share convergent disease features. A common symptom of these diseases is …
CRISPR/Cas9 mediated gene correction ameliorates abnormal phenotypes in spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cells
L He, S Wang, L Peng, H Zhao, S Li, X Han… - Translational …, 2021 - nature.com
Abstract Spinocerebellar ataxia type 3/Machado–Joseph disease (SCA3/MJD) is a
progressive autosomal dominant neurodegenerative disease caused by abnormal CAG …
progressive autosomal dominant neurodegenerative disease caused by abnormal CAG …
Creatine supplementation with exercise reduces α-synuclein oligomerization and necroptosis in Parkinson's disease mouse model
YH Leem, JS Park, JE Park, DY Kim, HS Kim - The Journal of Nutritional …, 2024 - Elsevier
Parkinson's disease (PD) is an incurable neurological disorder that causes typical motor
deficits. In this study, we investigated the effects of creatine supplementation and exercise in …
deficits. In this study, we investigated the effects of creatine supplementation and exercise in …
Mitochondria and other organelles in neural development and their potential as therapeutic targets in neurodegenerative diseases
S Zhang, J Zhao, Z Quan, H Li, H Qing - Frontiers in neuroscience, 2022 - frontiersin.org
The contribution of organelles to neural development has received increasing attention.
Studies have shown that organelles such as mitochondria, endoplasmic reticulum (ER) …
Studies have shown that organelles such as mitochondria, endoplasmic reticulum (ER) …
[HTML][HTML] From pathogenesis to novel therapeutics for spinocerebellar ataxia type 3: evading potholes on the way to translation
Abstract Spinocerebellar ataxia type 3 (SCA3), also known as Machado–Joseph disease
(MJD), is a neurodegenerative disorder caused by a polyglutamine expansion in the ATXN3 …
(MJD), is a neurodegenerative disorder caused by a polyglutamine expansion in the ATXN3 …