Today, many thousands of recombinant proteins, ranging from cytosolic enzymes to
membrane-bound proteins, have been successfully produced in baculovirus-infected insect …

Protein production for structural and biophysical studies, functional assays, biomarkers,
mechanistic studies in vitro and in vivo, but also for therapeutic applications in pharma …

Abstract The melanocortin-4 receptor (MC4R), a hypothalamic master regulator of energy
homeostasis and appetite, is a class A G-protein-coupled receptor and a prime target for the …

A diverse antibody repertoire is essential for humoral immunity. Antibody diversification
requires the introduction of deoxyuridine (dU) mutations within immunoglobulin genes to …

Most eukaryotic proteins exist as large multicomponent assemblies with many subunits,
which act in concert to catalyze specific cellular activities. Many of these molecular machines …

At low emittance synchrotron sources it has become possible to perform structure
determinations from the measurement of multiple microcrystals which were previously …

Lentiviruses contain accessory genes that have evolved to counteract the effects of host
cellular defence proteins that inhibit productive infection. One such restriction factor …

A major impact of genome projects on human health will be their contribution to the
understanding of protein function. Proteins are the engines of biological systems, nearly all …

The baculovirus expression vector system (BEVS) is widely established as a highly useful
and effective eukaryotic expression system. Thousands of soluble and membrane proteins …

Purified recombinant proteins are key reagents in academic and industrial research. The
ability to make these proteins quickly often relies on the availability of higher eukaryotic cell …