Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms
This paper reviews the research evidence concerning the intergenerational transmission of
trauma effects and the possible role of epigenetic mechanisms in this transmission. Two …
trauma effects and the possible role of epigenetic mechanisms in this transmission. Two …
DNA methylation-based predictors of health: applications and statistical considerations
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …
development, because, unlike static genetic risk estimates, DNA methylation varies …
Holocaust exposure induced intergenerational effects on FKBP5 methylation
Background The involvement of epigenetic mechanisms in intergenerational transmission of
stress effects has been demonstrated in animals but not in humans. Methods Cytosine …
stress effects has been demonstrated in animals but not in humans. Methods Cytosine …
Developmental trajectories of early life stress and trauma: a narrative review on neurobiological aspects beyond stress system dysregulation
Early life stressors display a high universal prevalence and constitute a major public health
problem. Prolonged psychoneurobiological alterations as sequelae of early life stress (ELS) …
problem. Prolonged psychoneurobiological alterations as sequelae of early life stress (ELS) …
Comorbidity between post-traumatic stress disorder and major depressive disorder: alternative explanations and treatment considerations
Approximately half of people with post-traumatic stress disorder (PTSD) also suffer from
Major Depressive Disorder (MDD). The current paper examines evidence for two …
Major Depressive Disorder (MDD). The current paper examines evidence for two …
Effects of the social environment and stress on glucocorticoid receptor gene methylation: a systematic review
The early-life social environment can induce stable changes that influence
neurodevelopment and mental health. Research focused on early-life adversity revealed …
neurodevelopment and mental health. Research focused on early-life adversity revealed …
Stress, glucocorticoids and memory: implications for treating fear-related disorders
D de Quervain, L Schwabe… - Nature Reviews …, 2017 - nature.com
Glucocorticoid stress hormones are crucially involved in modulating mnemonic processing
of emotionally arousing experiences. They enhance the consolidation of new memories …
of emotionally arousing experiences. They enhance the consolidation of new memories …
Neurobiology of early life adversity: A systematic review of meta-analyses towards an integrative account of its neurobiological trajectories to mental disorders
Y Hakamata, Y Suzuki, H Kobashikawa… - Frontiers in …, 2022 - Elsevier
Adverse childhood experiences (ACEs) may leave long-lasting neurobiological scars,
increasing the risk of develo** mental disorders in later life. However, no review has …
increasing the risk of develo** mental disorders in later life. However, no review has …
Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring
Objective Differential effects of maternal and paternal posttraumatic stress disorder (PTSD)
have been observed in adult offspring of Holocaust survivors in both glucocorticoid receptor …
have been observed in adult offspring of Holocaust survivors in both glucocorticoid receptor …
Modeling gene× environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent to
which genetic and environmental risk factors contribute to individual clinical outcomes is …
which genetic and environmental risk factors contribute to individual clinical outcomes is …