Neural circuits of interoception

GG Berntson, SS Khalsa - Trends in neurosciences, 2021 - cell.com
The present paper considers recent progress in our understanding of the afferent/ascending
neural pathways and neural circuits of interoception. Of particular note is the extensive role …

Preoperative exercise interventions to optimize continence outcomes following radical prostatectomy

SF Mungovan, SV Carlsson, GC Gass… - Nature Reviews …, 2021 - nature.com
Urinary incontinence is a common and predictable consequence among men with localized
prostate cancer who have undergone radical prostatectomy. Despite advances in the …

PIEZO2 in sensory neurons and urothelial cells coordinates urination

KL Marshall, D Saade, N Ghitani, AM Coombs… - Nature, 2020 - nature.com
Henry Miller stated that “to relieve a full bladder is one of the great human joys”. Urination is
critically important in health and ailments of the lower urinary tract cause high pathological …

A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution

S Nardone, R De Luca, A Zito, N Klymko… - Nature …, 2024 - nature.com
Abstract The “dorsal pons”, or “dorsal pontine tegmentum”(dPnTg), is part of the brainstem. It
is a complex, densely packed region whose nuclei are involved in regulating many vital …

[HTML][HTML] Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception

MG Dalghi, WG Ruiz, DR Clayton, N Montalbetti… - JCI insight, 2021 - ncbi.nlm.nih.gov
The mechanisms that link visceral mechanosensation to the perception of internal organ
status (ie, interoception) remain elusive. In response to bladder filling, the urothelium …

Flexible scaling and persistence of social vocal communication

J Chen, JE Markowitz, V Lilascharoen, S Taylor… - Nature, 2021 - nature.com
Innate vocal sounds such as laughing, screaming or crying convey one's feelings to others.
In many species, including humans, scaling the amplitude and duration of vocalizations is …

The mysteries of menopause and urogynecologic health: clinical and scientific gaps

M Alperin, L Burnett, E Lukacz, L Brubaker - Menopause, 2019 - journals.lww.com
Objectives: A significant body of knowledge implicates menopausal estrogen levels in the
pathogenesis of the common pelvic floor disorders (PFDs). These health conditions …

Losing trust in body sensations: Interoceptive awareness and depression symptom severity among primary care patients

J Dunne, M Flores, R Gawande… - Journal of affective …, 2021 - Elsevier
Background Interoceptive dysfunction is emerging as an important biomarker for mental
illnesses, such as depression which is a leading cause of disability and death worldwide …

A corticopontine circuit for initiation of urination

J Yao, Q Zhang, X Liao, Q Li, S Liang, X Li… - Nature …, 2018 - nature.com
Urination (also called micturition) is thought to be regulated by a neural network that is
distributed in both subcortical and cortical regions. Previously, urination-related neurons …

[HTML][HTML] Proper wiring of newborn neurons to control bladder function after complete spinal cord injury

F Hao, F Jia, P Hao, H Duan, Z Wang, Y Fan, W Zhao… - Biomaterials, 2023 - Elsevier
Activation of endogenous neurogenesis by bioactive materials enables restoration of
sensory/motor function after complete spinal cord injury (SCI) via formation of new relay …