Most currently available antidepressants target monoamine neurotransmitter function.
However, a purely neurotransmitter-based explanation for antidepressant drug action is …

Ketamine, a drug introduced in the 1960s as an anesthetic agent and still used for that
purpose, has garnered marked interest over the past two decades as an emerging treatment …

Depression is a leading cause of disability worldwide and improving its treatment is a core
research priority for future programmes. A change in the view of psychological and …

In this paper, we present the development of the Altered States Database (ASDB), an open-
science project based on a systematic literature review. The ASDB contains psychometric …

Ketamine commonly and rapidly induces dissociative and other altered states of
consciousness (ASCs) in humans. However, the neural mechanisms that contribute to these …

Major depressive disorder (MDD) is one of the most prevalent conditions in psychiatry.
Patients who do not respond to traditional monoaminergic antidepressant treatments have …

Electroconvulsive therapy (ECT) and ketamine treatment both induce rapidly acting
antidepressant effects in patients with major depressive disorder unresponsive to standard …

Rationale: Psychedelic research re-emerged from a period of suppression into the so-called
psychedelic renaissance. In parallel, most media reporting has shifted from the …

Rationale and objectives Differences among psychedelic substances regarding their
subjective experiences are clinically and scientifically interesting. Quantitative linguistic …

Abstract Major Depressive Disorder (MDD) is one of the most prevalent psychiatric disorders
worldwide. About 20–30% of patients do not respond to the standard …