Osteoarthritis (OA) is the most common joint disease, generating pain, disability, and
socioeconomic costs worldwide. Currently there are no approved disease-modifying drugs …

With its wide distribution in soft and hard connective tissues, collagen is the most abundant
of animal proteins. In vitro, natural collagen can be formed into highly organized, three …

Background Atopic dermatitis (AD) is a prevalent inflammatory skin disease with a complex
pathogenesis involving immune cell and epidermal abnormalities. Despite whole tissue …

Collagen VI represents a remarkable extracellular matrix molecule, and in the past few
years, studies of this molecule have revealed its involvement in a wide range of tissues and …

Collagens are the most abundant proteins in mammals. The collagen family comprises 28
members that contain at least one triple-helical domain. Collagens are deposited in the …

Gelatin obtained from pig skin constitutes about 50% of world production and is mainly
composed of collagen extracted from skin by acidic baths and thermal treatments. The …

Asthma and allergy are common conditions with complex etiologies involving both genetic
and environmental contributions. Recent genome‐wide association studies (GWAS) and …

Hsp47, a collagen-specific molecular chaperone that localizes in the endoplasmic reticulum
(ER), is indispensable for molecular maturation of collagen. Hsp47, which is encoded by the …

The extracellular matrix (ECM) is a highly dynamic and heterogeneous structure that plays
multiple roles in living organisms. Its integrity and homeostasis are crucial for normal tissue …

The superficial epidermis is a stratified epithelium largely composed of keratinocytes that are
formed by division of cells in the basal layer, and give rise to several distinguishable layers …