At sites of vascular injury, platelets come into contact with subendothelial collagen, which
triggers their activation and the formation of a hemostatic plug. Besides glycoprotein Ib …

Significantly, much of the activity of Citrus flavonoids appears to impact blood and
microvascular endothelial cells, and it is not surprising that the two main areas of research …

Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall
and soluble agonists, which initiate platelet activation, leading to formation of hemostatic …

In recent years, cardiovascular disease (CVD) has become more prevalent. Premature
death is a factor in CVD being associated with diabetes. According to epidemiological …

Rap1b, an abundant small GTPase in platelets, becomes rapidly activated upon stimulation
with agonists. Though it has been implicated to act downstream from G protein–coupled …

Background: Dietary flavonoids are known for their antiplatelet activity resulting in
cardiovascular protection, although the specific mechanisms by which this inhibition occurs …

The serine-threonine kinase Akt has been established as an important signaling
intermediate in regulating cell survival, cell cycle progression, as well as agonist-induced …

The importance of the second messengers calcium (Ca2+) and diacylglycerol (DAG) in
platelet signal transduction was established more than 30 years ago. Whereas protein …

Background The ingestion of flavonoids has been reported to be associated with reduced
cardiovascular disease risk. Quercitrin is a common flavonoid in nature, and it exhibits …

Background Cardiovascular disease is one of the most concerning chronic diseases in the
world. Many studies have shown that platelet overactivation is a very important factor in the …