The vascular cellular adhesion molecule-1 (VCAM-1) is a protein that canonically
participates in the adhesion and transmigration of leukocytes to the interstitium during …

Mesenchymal stem cell (MSC)-based therapy has been considered as a promising
approach targeting a variety of intractable diseases due to remarkable multiple effect of …

We have previously identified exosomes as the paracrine factor secreted by mesenchymal
stem cells. Recently, we found that the key features of reperfusion injury, namely loss of …

Ischemic heart disease is the leading cause of death worldwide. Myocardial infarction
results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and …

BACKGROUND: Cardiac progenitors (CPC) mediate cardioprotection via paracrine effects.
To date, most of studies focused on secreted paracrine proteins. Here we investigated the …

The fabrication of 3D tissues retaining the original functions of tissues/organs in vitro is
crucial for optimal tissue engineering and regenerative medicine. The fabrication of 3D …

To realize cardiac regeneration using human induced pluripotent stem cells (hiPSCs),
strategies for cell preparation, tissue engineering and transplantation must be explored …

Exosomes, a group of vesicles originating from the multivesicular bodies (MVBs), are
released into the extracellular space when MVBs fuse with the plasma membrane …

Stem cell-derived sheet engineering has been developed as the next-generation treatment
for myocardial infarction (MI) and offers attractive advantages in comparison with direct stem …

After the biotech medicine era, regenerative medicine is expected to be an advanced
medicine that is capable of curing patients with difficult-to-treat diseases and physically …