BACKGROUND The idea that memory is stored as enduring changes in the brain dates
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …

Episodic memory reflects the ability to recollect the temporal and spatial context of past
experiences. Episodic memories depend on the hippocampus but have been proposed to …

Little is understood about how engrams, sparse groups of neurons that store memories, are
formed endogenously. Here, we combined calcium imaging, activity tagging, and …

While initial encoding of contextual memories involves the strengthening of hippocampal
circuits, these memories progressively mature to stabilized forms in neocortex and become …

Experience-dependent myelination is hypothesized to shape neural circuit function and
subsequent behavioral output. Using a contextual fear memory task in mice, we demonstrate …

The roles of the hippocampus and prefrontal cortex (PFC) in memory processing—
individually or in concert—are a major topic of interest in memory research. These brain …

Memories of fearful events can last a lifetime. The prelimbic (PL) cortex, a subregion of
prefrontal cortex, plays a critical role in fear memory retrieval over time. Most studies have …

What happens to memories as days, weeks and years go by has long been a fundamental
question in neuroscience and psychology. For decades, researchers have attempted to …

Oxytocin is a well-known neurohypophysial hormone that plays an important role in
behavioral anxiety and nociception. Two major forms of long-term potentiation, presynaptic …

Altered sensory processing has been an important feature of the clinical descriptions of
autism spectrum disorder (ASD). There is evidence that sensory dysregulation arises early …