Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity

A Hammarstedt, S Gogg, S Hedjazifar… - Physiological …, 2018 - journals.physiology.org
The subcutaneous adipose tissue (SAT) is the largest and best storage site for excess lipids.
However, it has a limited ability to expand by recruiting and/or differentiating available …

Extracellular matrix remodeling of adipose tissue in obesity and metabolic diseases

FJ Ruiz-Ojeda, A Méndez-Gutiérrez… - International journal of …, 2019 - mdpi.com
The extracellular matrix (ECM) is a network of different proteins and proteoglycans that
controls differentiation, migration, repair, survival, and development, and it seems that its …

Heterogeneity of adipose tissue in development and metabolic function

T Schoettl, IP Fischer, S Ussar - Journal of Experimental …, 2018 - journals.biologists.com
Adipose tissue is a central metabolic organ. Unlike other organs, adipose tissue is
compartmentalized into individual depots and distributed throughout the body. These …

Mechanisms of obesity-and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review

R Ruze, J Song, X Yin, Y Chen, R Xu… - Signal transduction and …, 2023 - nature.com
Research on obesity-and diabetes mellitus (DM)-related carcinogenesis has expanded
exponentially since these two diseases were recognized as important risk factors for …

Obesity and metabolic syndrome associated with systemic inflammation and the impact on the male reproductive system

K Leisegang, R Henkel… - American journal of …, 2019 - Wiley Online Library
Obesity and metabolic syndrome (MetS) are global epidemics, driven by an obesogenic
environment. This is mediated by complex underlying pathophysiology, in which chronic …

Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial

MA Heiskanen, KK Motiani, A Mari, V Saunavaara… - Diabetologia, 2018 - Springer
Aims/hypothesis Pancreatic fat accumulation may contribute to the development of beta cell
dysfunction. Exercise training improves whole-body insulin sensitivity, but its effects on …

Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans

M Takahashi, M Hori, R Ishigamori, M Mutoh… - Cancer …, 2018 - Wiley Online Library
Obesity, type 2 diabetes mellitus (T2 DM) and aging are associated with pancreatic cancer
risk, but the mechanisms of pancreatic cancer development caused by these factors are not …

Microbiota in pancreatic diseases: a review of the literature

T Schepis, SS De Lucia, EC Nista, V Manilla… - Journal of Clinical …, 2021 - mdpi.com
The gut microbiota is a critical element in the balance between human health and disease.
Its impairment, defined as dysbiosis, is associated with gastroenterological and systemic …

Fatty infiltration of the pancreas: a systematic concept analysis

MA Mahyoub, M Elhoumed, AH Maqul… - Frontiers in …, 2023 - frontiersin.org
Fatty infiltration of the pancreas (FIP) has been recognized for nearly a century, yet many
aspects of this condition remain unclear. Regular literature reviews on the diagnosis …

Intrapancreatic fat, pancreatitis, and pancreatic cancer

AC Lilly, I Astsaturov, EA Golemis - Cellular and Molecular Life Sciences, 2023 - Springer
Pancreatic cancer is typically detected at an advanced stage, and is refractory to most forms
of treatment, contributing to poor survival outcomes. The incidence of pancreatic cancer is …