Towards individualized therapy for metastatic renal cell carcinoma
Over the past decade, the treatment landscape for patients with metastatic renal cell
carcinoma (RCC) has evolved dramatically. The therapeutic options available have …
carcinoma (RCC) has evolved dramatically. The therapeutic options available have …
Familial kidney cancer: implications of new syndromes and molecular insights
Context Hereditary cases account for about 5% of all cases of renal cell carcinoma (RCC).
With advances in next-generation sequencing, several new hereditary syndromes have …
With advances in next-generation sequencing, several new hereditary syndromes have …
Prevalence of germline mutations in cancer susceptibility genes in patients with advanced renal cell carcinoma
Importance Identification of patients with hereditary renal cell carcinoma (RCC) is important
for cancer screening and, in patients with advanced disease, for guiding treatment. The …
for cancer screening and, in patients with advanced disease, for guiding treatment. The …
Universal germline genetic testing for hereditary cancer syndromes in patients with solid tumor cancer
ED Esplin, SM Nielsen, SL Bristow, JE Garber… - JCO Precision …, 2022 - ascopubs.org
Historically, professional society guidelines have recommended limited genetic testing for
hereditary cancer syndromes (HCS) to patients with cancer thought to be at highest risk for …
hereditary cancer syndromes (HCS) to patients with cancer thought to be at highest risk for …
Genetic risk assessment for hereditary renal cell carcinoma: Clinical consensus statement
G Bratslavsky, N Mendhiratta, M Daneshvar… - Cancer, 2021 - Wiley Online Library
Background Although renal cell carcinoma (RCC) is believed to have a strong hereditary
component, there is a paucity of published guidelines for genetic risk assessment. A panel of …
component, there is a paucity of published guidelines for genetic risk assessment. A panel of …
Cytoreductive surgery, systemic treatment, genetic evaluation, and patient perspective in a young adult with metastatic renal cell carcinoma
A man aged 41 years who had a past medical history significant for bilateral lower extremity
varicosities and a prior 20‐pack‐year smoking history reported several days of fatigue to his …
varicosities and a prior 20‐pack‐year smoking history reported several days of fatigue to his …
Artificial neural networks as a way to predict future kidney cancer incidence in the United States
Introduction The incidence of kidney cancer is increasing; it could be counteracted with new
ways to predict and detect it. We aimed to implement an artificial neural network in order to …
ways to predict and detect it. We aimed to implement an artificial neural network in order to …
Clinical and molecular characterization of microphthalmia-associated transcription factor (MITF)-related renal cell carcinoma
Objectives To characterize the clinical presentation, genomic alterations, pathologic
phenotype and clinical management of microphthalmia-associated transcription factor …
phenotype and clinical management of microphthalmia-associated transcription factor …
Frequency of pathogenic germline variants in cancer susceptibility genes in 1336 renal cell carcinoma cases
B Yngvadottir, A Andreou… - Human Molecular …, 2022 - academic.oup.com
Renal cell carcinoma (RCC) occurs in a number of cancer predisposition syndromes, but the
genetic architecture of susceptibility to RCC is not well defined. We investigated the …
genetic architecture of susceptibility to RCC is not well defined. We investigated the …
Germline variants identified in patients with early-onset renal cell carcinoma referred for germline genetic testing
Background Despite guidelines recommending genetic counseling for patients with early-
onset renal cell carcinoma (RCC), studies interrogating the spectrum of germline mutations …
onset renal cell carcinoma (RCC), studies interrogating the spectrum of germline mutations …