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Challenges and opportunities for the next generation of cardiovascular tissue engineering
Engineered cardiac tissues derived from human induced pluripotent stem cells offer unique
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …
Excessive Trabeculation of the Left Ventricle: JACC: Cardiovascular Imaging Expert Panel Paper
Excessive trabeculation, often referred to as “noncompacted” myocardium, has been
described at all ages, from the fetus to the adult. Current evidence for myocardial …
described at all ages, from the fetus to the adult. Current evidence for myocardial …
Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages
Heart development is a continuous process involving significant remodeling during
embryogenesis and neonatal stages. To date, several groups have used single-cell …
embryogenesis and neonatal stages. To date, several groups have used single-cell …
Organ-specific endothelial cell differentiation and impact of microenvironmental cues on endothelial heterogeneity
Endothelial cells throughout the body are heterogeneous, and this is tightly linked to the
specific functions of organs and tissues. Heterogeneity is already determined from …
specific functions of organs and tissues. Heterogeneity is already determined from …
Proliferation and maturation: janus and the art of cardiac tissue engineering
During cardiac development and morphogenesis, cardiac progenitor cells differentiate into
cardiomyocytes that expand in number and size to generate the fully formed heart. Much is …
cardiomyocytes that expand in number and size to generate the fully formed heart. Much is …
Placental inflammation leads to abnormal embryonic heart development
Background: Placental heart development and embryonic heart development occur in
parallel, and these organs have been proposed to exert reciprocal regulation during …
parallel, and these organs have been proposed to exert reciprocal regulation during …
Single-cell RNA sequencing to identify cellular heterogeneity and targets in cardiovascular diseases: from bench to bedside
The mechanisms of cardiovascular diseases (CVDs) remain incompletely elucidated. Single-
cell RNA sequencing (scRNA-seq) has enabled the profiling of single-cell transcriptomes at …
cell RNA sequencing (scRNA-seq) has enabled the profiling of single-cell transcriptomes at …
The insulin-like growth factor signalling pathway in cardiac development and regeneration
S Díaz Del Moral, M Benaouicha… - International journal of …, 2021 - mdpi.com
Insulin and Insulin-like growth factors (IGFs) perform key roles during embryonic
development, regulating processes of cell proliferation and survival. The IGF signalling …
development, regulating processes of cell proliferation and survival. The IGF signalling …
Single-cell technologies to decipher cardiovascular diseases
Cardiovascular disease remains the leading cause of death worldwide. A deeper
understanding of the multicellular composition and molecular processes may help to identify …
understanding of the multicellular composition and molecular processes may help to identify …
Why is endothelial resilience key to maintain cardiac health?
Myocardial injury as induced by myocardial infarction results in tissue ischemia, which
critically incepts cardiomyocyte death. Endothelial cells play a crucial role in restoring …
critically incepts cardiomyocyte death. Endothelial cells play a crucial role in restoring …