The precise temporal and spatial coordination of histone lysine methylation dynamics across
the epigenome regulates virtually all DNA-templated processes. A large number of histone …

A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …

Identifying and understanding changes in cancer genomes is essential for the development
of targeted therapeutics. Here we analyse systematically more than 70 pairs of primary …

LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt,
Notch and epidermal growth factor signals. Here we find that the related RNF43 and ZNRF3 …

Synonymous mutations change the sequence of a gene without directly altering the
sequence of the encoded protein. Here, we present evidence that these" silent" mutations …

Fibroblast growth factors (FGFs) are involved in a variety of cellular processes, such as
stemness, proliferation, anti‐apoptosis, drug resistance, and angiogenesis. Here, FGF …

We recently proposed that competitive endogenous RNAs (ceRNAs) sequester microRNAs
to regulate mRNA transcripts containing common microRNA recognition elements (MREs) …

The application of primary organoid cultures containing epithelial and mesenchymal
elements to cancer modeling holds promise for combining the accurate multilineage …

Recurring deletions of chromosome 7 and 7q [− 7/del (7q)] occur in myelodysplastic
syndromes and acute myeloid leukemia (AML) and are associated with poor prognosis …

Pancreatic ductal adenocarcinoma (PDA) remains a lethal malignancy despite much
progress concerning its molecular characterization. PDA tumours harbour four signature …