Acute lymphoblastic leukaemia
H Inaba, M Greaves, CG Mullighan - The Lancet, 2013 - thelancet.com
Acute lymphoblastic leukaemia occurs in both children and adults but its incidence peaks
between 2 and 5 years of age. Causation is multifactorial and exogenous or endogenous …
between 2 and 5 years of age. Causation is multifactorial and exogenous or endogenous …
N6-methyladenosine methyltransferases: functions, regulation, and clinical potential
W Huang, TQ Chen, K Fang, ZC Zeng, H Ye… - Journal of Hematology & …, 2021 - Springer
Abstract N6-methyladenosine (m6A) has emerged as an abundant modification throughout
the transcriptome with widespread functions in protein-coding and noncoding RNAs. It …
the transcriptome with widespread functions in protein-coding and noncoding RNAs. It …
Inherited NUDT15 Variant Is a Genetic Determinant of Mercaptopurine Intolerance in Children With Acute Lymphoblastic Leukemia
Purpose Mercaptopurine (MP) is the mainstay of curative therapy for acute lymphoblastic
leukemia (ALL). We performed a genome-wide association study (GWAS) to identify …
leukemia (ALL). We performed a genome-wide association study (GWAS) to identify …
The genetics and molecular biology of T-ALL
T Girardi, C Vicente, J Cools… - Blood, The Journal of …, 2017 - ashpublications.org
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy caused by the
accumulation of genomic lesions that affect the development of T cells. For many years, it …
accumulation of genomic lesions that affect the development of T cells. For many years, it …
Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia
There is incomplete understanding of genetic heterogeneity and clonal evolution during
cancer progression. Here we use deep whole-exome sequencing to describe the clonal …
cancer progression. Here we use deep whole-exome sequencing to describe the clonal …
Relapsed childhood acute lymphoblastic leukaemia
D Bhojwani, CH Pui - The lancet oncology, 2013 - thelancet.com
With steadily improved cure rates for children with newly diagnosed acute lymphoblastic
leukaemia (ALL), treating relapsed ALL has become increasingly challenging largely due to …
leukaemia (ALL), treating relapsed ALL has become increasingly challenging largely due to …
Prognostic significance of minimal residual disease in high risk B-ALL: a report from Children's Oncology Group study AALL0232
Minimal residual disease (MRD) is highly prognostic in pediatric B-precursor acute
lymphoblastic leukemia (B-ALL). In Children's Oncology Group high-risk B-ALL study …
lymphoblastic leukemia (B-ALL). In Children's Oncology Group high-risk B-ALL study …
A 50-year journey to cure childhood acute lymphoblastic leukemia
CH Pui, WE Evans - Seminars in hematology, 2013 - Elsevier
The 50th anniversary of Seminars in Hematology coincides with the 50th anniversary of St.
Jude Children's Research Hospital, and both milestones are inexorably linked to studies …
Jude Children's Research Hospital, and both milestones are inexorably linked to studies …
Dietary approaches to cancer therapy
M Tajan, KH Vousden - Cancer cell, 2020 - cell.com
The concept that dietary changes could improve the response to cancer therapy is extremely
attractive to many patients, who are highly motivated to take control of at least some aspect …
attractive to many patients, who are highly motivated to take control of at least some aspect …
New insights into the pathophysiology and therapy of adult acute lymphoblastic leukemia
E Jabbour, S O'Brien, M Konopleva, H Kantarjian - Cancer, 2015 - Wiley Online Library
Significant advances have been made in the last decade toward a better understanding of
the disease pathogenesis and the development of novel therapies that target specific …
the disease pathogenesis and the development of novel therapies that target specific …