Celebrating 20 years of genetic discoveries in legume nodulation and symbiotic nitrogen fixation
Since 1999, various forward-and reverse-genetic approaches have uncovered nearly 200
genes required for symbiotic nitrogen fixation (SNF) in legumes. These discoveries …
genes required for symbiotic nitrogen fixation (SNF) in legumes. These discoveries …
Clusterin in Alzheimer's disease: mechanisms, genetics, and lessons from other pathologies
Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several
physiological and pathological states, including Alzheimer's disease (AD). With a prominent …
physiological and pathological states, including Alzheimer's disease (AD). With a prominent …
The reactome pathway knowledgebase
Abstract The Reactome Knowledgebase (https://reactome. org) provides molecular details of
signal transduction, transport, DNA replication, metabolism, and other cellular processes as …
signal transduction, transport, DNA replication, metabolism, and other cellular processes as …
SIGNOR 2.0, the SIGnaling network open resource 2.0: 2019 update
Abstract The SIGnaling Network Open Resource 2.0 (SIGNOR 2.0) is a public repository that
stores signaling information as binary causal relationships between biological entities. The …
stores signaling information as binary causal relationships between biological entities. The …
T follicular helper cell heterogeneity: time, space, and function
T follicular helper (Tfh) cells play a crucial role in orchestrating the humoral arm of adaptive
immune responses. Mature Tfh cells localize to follicles in secondary lymphoid organs (SLO …
immune responses. Mature Tfh cells localize to follicles in secondary lymphoid organs (SLO …
[HTML][HTML] Identification of therapeutic targets for amyotrophic lateral sclerosis using PandaOmics–an AI-enabled biological target discovery platform
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease with ill-defined
pathogenesis, calling for urgent developments of new therapeutic regimens. Herein, we …
pathogenesis, calling for urgent developments of new therapeutic regimens. Herein, we …
Lessons from primary immunodeficiencies: autoimmune regulator and autoimmune polyendocrinopathy‐candidiasis‐ectodermal dystrophy
GM Constantine, MS Lionakis - Immunological reviews, 2019 - Wiley Online Library
The discovery of the autoimmune regulator (AIRE) protein and the delineation of its critical
contributions in the establishment of central immune tolerance has significantly expanded …
contributions in the establishment of central immune tolerance has significantly expanded …
[HTML][HTML] Hepatitis C: From inflammatory pathogenesis to anti-inflammatory/hepatoprotective therapy
Hepatitis C virus (HCV) infection commonly causes progressive liver diseases that
deteriorate from chronic inflammation to fibrosis, cirrhosis and even to hepatocellular …
deteriorate from chronic inflammation to fibrosis, cirrhosis and even to hepatocellular …
Pharmacometabonomics: data processing and statistical analysis
J Fu, Y Zhang, J Liu, X Lian, J Tang… - Briefings in …, 2021 - academic.oup.com
Individual variations in drug efficacy, side effects and adverse drug reactions are still
challenging that cannot be ignored in drug research and development. The aim of …
challenging that cannot be ignored in drug research and development. The aim of …
Circadian clocks in fish—what have we learned so far?
IA Frøland Steindal, D Whitmore - Biology, 2019 - mdpi.com
Zebrafish represent the one alternative vertebrate, genetic model system to mice that can be
easily manipulated in a laboratory setting. With the teleost Medaka (Oryzias latipes), which …
easily manipulated in a laboratory setting. With the teleost Medaka (Oryzias latipes), which …