Browning of the white adipose tissue regulation: New insights into nutritional and metabolic relevance in health and diseases

SA Machado, G Pasquarelli-do-Nascimento… - Nutrition & …, 2022 - Springer
Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

[HTML][HTML] Protective role of melatonin and its metabolites in skin aging

G Bocheva, RM Slominski, Z Janjetovic, TK Kim… - International journal of …, 2022 - mdpi.com
The skin, being the largest organ in the human body, is exposed to the environment and
suffers from both intrinsic and extrinsic aging factors. The skin aging process is …

Mechanisms of melatonin in obesity: a review

Q Guan, Z Wang, J Cao, Y Dong, Y Chen - International journal of …, 2021 - mdpi.com
Obesity and its complications have become a prominent global public health problem that
severely threatens human health. Melatonin, originally known as an effective antioxidant, is …

Melatonin: both a messenger of darkness and a participant in the cellular actions of non-visible solar radiation of near infrared light

DX Tan, RJ Reiter, S Zimmerman, R Hardeland - Biology, 2023 - mdpi.com
Simple Summary Environmental light exposure is an important factor for human health that
impacts the biological clock of organisms. Melatonin usually serves as a chemical …

Murine models of obesity

T Martins, C Castro-Ribeiro, S Lemos, T Ferreira… - Obesities, 2022 - mdpi.com
Obesity, classified as an epidemic by the WHO, is a disease that continues to grow
worldwide. Obesity results from abnormal or excessive accumulation of fat and usually leads …

[HTML][HTML] Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/AMPK/PGC1α pathway and …

D Salagre, M Navarro-Alarcón, M Villalón-Mir… - Biomedicine & …, 2024 - Elsevier
Melatonin acute treatment limits obesity of young Zücker diabetic fatty (ZDF) rats by non-
shivering thermogenesis (NST). We recently showed melatonin chronically increases the …

Impaired melatonin secretion, oxidative stress and metabolic syndrome in night shift work

S Hohor, C Mandanach, A Maftei, CA Zugravu… - Antioxidants, 2023 - mdpi.com
Metabolic syndrome has been associated in many studies with working in shifts. Even if the
mechanistic details are not fully understood, forced sleep deprivation and exposure to light …

[HTML][HTML] Melatonin Improves Skeletal Muscle Structure and Oxidative Phenotype by Regulating Mitochondrial Dynamics and Autophagy in Zücker Diabetic Fatty Rat

D Salagre, E Raya Álvarez, CM Cendan, S Aouichat… - Antioxidants, 2023 - mdpi.com
Obesity-induced skeletal muscle (SKM) inflexibility is closely linked to mitochondrial
dysfunction. The present study aimed to evaluate the effects of melatonin on the red vastus …

Melatonin and redox homeostasis

S Süzen, MC Atayik, H Sirinzade… - Melatonin …, 2022 - melatonin-research.net
Redox homeostasis and redox signaling are constituents of preservation of a normal
physiological state. Whereas the equilibrium between oxidants and nucleophiles is …

[HTML][HTML] Dose-dependent effect of melatonin on bat thermogenesis in zücker diabetic fatty rat: future clinical implications for obesity

S Aouichat, E Raya, A Molina-Carballo… - Antioxidants, 2022 - mdpi.com
Experimental data have revealed that melatonin at high doses reduced obesity and
improved metabolic outcomes in experimental models of obesity, mainly by enhancing …