The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Lipotoxicity, originally used to describe the destructive effects of excess fat accumulation on
glucose metabolism, causes functional impairments in several metabolic pathways, both in …

Insulin resistance is a major underlying mechanism for the “metabolic syndrome”, which is
also known as insulin resistance syndrome. Metabolic syndrome is increasing at an …

Insulin resistance is a complex metabolic disorder that defies explanation by a single
etiological pathway. Accumulation of ectopic lipid metabolites, activation of the unfolded …

Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol
(DAG) generated in the different cellular compartments in various physiological processes …

OBJECTIVE We examined the role of butyric acid, a short-chain fatty acid formed by
fermentation in the large intestine, in the regulation of insulin sensitivity in mice fed a high-fat …

Nearly unlimited supplies of energy-dense foods and technologies that encourage
sedentary behaviour have introduced a new threat to the survival of our species: obesity and …

Insulin signaling can be modulated by several isoforms of PKC in peripheral tissues. Here,
we assessed whether one specific isoform, PKC-θ, was expressed in critical CNS regions …

Obesity and its associated health disorders and costs are increasing. Males and females
differ in terms of how and where body fat is stored, the hormones they secrete in proportion …

Increased fat deposition in skeletal muscle is associated with insulin resistance. However,
exercise increases both intramyocellular fat stores and insulin sensitivity, a phenomenon …