Owing to renal reabsorption and the loss of uricase activity, uric acid (UA) is strictly
maintained at a higher physiological level in humans than in other mammals, which …

Gout and hyperuricemia are present in 25% and 60% of patients with chronic kidney
disease (CKD), respectively. Despite the common association, the role of uric acid in the …

Uric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as
an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in …

Urate is a cause of gout, kidney stones, and acute kidney injury from tumor lysis syndrome,
but its relationship to kidney disease, cardiovascular disease, and diabetes remains …

Substantial evidence suggests that chronic hyperuricemia is an independent risk factor for
hypertension, metabolic syndrome, chronic kidney disease (CKD) and cardiovascular …

Uric acid, once viewed as an inert metabolic end-product of purine metabolism, has been
recently incriminated in a number of chronic disease states, including hypertension …

In diseases of the central nervous system, such as Alzheimer's disease (AD), Parkinson's
disease (PD), stroke, amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and …

Asymptomatic hyperuricaemia affects~ 20% of the general population in the USA, with
variable rates in other countries. Historically, asymptomatic hyperuricaemia was considered …

Uric acid, generated from the metabolism of purines, has proven and emerging roles in
human disease. Serum uric acid is determined by production and the net balance of …

Xanthine oxidase inhibitors such as allopurinol and febuxostat have been the mainstay
urate-lowering therapy (ULT) for treating hyperuricaemia in patients with gout. However, not …