The aryl hydrocarbon (dioxin) receptor (AhR) has been studied for several decades largely
because of its critical role in xenobiotic-induced toxicity and carcinogenesis. Albeit this is a …

The aryl hydrocarbon receptor (AhR) exists in the absence of a ligand as a tetrameric
complex composed of a 95–105 kDa ligand binding subunit, a dimer of hsp90, and the …

Abstract The European Commission asked EFSA for a scientific opinion on the risks for
animal and human health related to the presence of dioxins (PCDD/Fs) and DL‐PCBs in …

The ability of a cancer cell to develop resistance to anoikis, a programmed cell death
process triggered by substratum detachment, is a critical step in the metastatic cascade …

The proteolytic degradation of transcription factors is an established mechanism of
regulating signal transduction pathways. Recent reports have suggested that the aryl …

Even before the first vertebrates appeared on our planet, the aryl hydrocarbon receptor
(AHR) gene was present to carry out one or more critical life functions. The vertebrate AHR …

Induction of drug-clearance pathways (Phase 1 and 2 enzymes and transporters) can have
important clinical consequences. Inducers can (1) increase the clearance of other drugs …

Dioxins are ubiquitous and persistent environmental contaminants whose background
levels are still reason for concern. There is mounting evidence from both epidemiological …

The aryl hydrocarbon (Ah) receptor (AhR) is a member of the basic helix‐loop‐helix PER‐
ARNT‐SIM (PAS) transcription factor family. Consistent with the notion that PAS proteins are …

The mouse aryl hydrocarbon receptor (mAhR) is a ligand-activated transcription factor that
exists in a tetrameric, core complex with a dimer of the 90-kDa heat shock protein, and the …