An international adult guideline for making clozapine titration safer by using six ancestry-based personalized dosing titrations, CRP, and clozapine levels

J De Leon, G Schoretsanitis, RL Smith… - …, 2022 - thieme-connect.com
This international guideline proposes improving clozapine package inserts worldwide by
using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest …

20‐year follow‐up study of physical morbidity and mortality in relationship to antipsychotic treatment in a nationwide cohort of 62,250 patients with schizophrenia …

H Taipale, A Tanskanen, J Mehtälä… - World …, 2020 - Wiley Online Library
Antipsychotics are effective in preventing relapses of schizophrenia, but it is generally
believed that their long‐term use is harmful for patients' physical well‐being. However, there …

Multiple adverse outcomes associated with antipsychotic use in people with dementia: population based matched cohort study

PLH Mok, MJ Carr, B Guthrie, DR Morales, A Sheikh… - bmj, 2024 - bmj.com
Objective To investigate risks of multiple adverse outcomes associated with use of
antipsychotics in people with dementia. Design Population based matched cohort study …

Psychiatry in the aftermath of COVID-19

E Vieta, V Pérez, C Arango - Revista de psiquiatria y salud …, 2020 - pmc.ncbi.nlm.nih.gov
At the time of the writing of this article, a substantial part of the world population is in partial
or total lockdown due to the pandemic caused by the SARS CoV-2 virus. This health …

[HTML][HTML] An umbrella review of adverse effects associated with antipsychotic medications: the need for complementary study designs

RTS Chow, D Whiting, L Favril, E Ostinelli… - Neuroscience & …, 2023 - Elsevier
Antipsychotic medications are widely prescribed in psychotic illnesses and other mental
disorders. Effectiveness is well-established, particularly for reducing symptoms such as …

A rational use of clozapine based on adverse drug reactions, pharmacokinetics, and clinical pharmacopsychology

J de Leon, CJ Ruan, G Schoretsanitis… - Psychotherapy and …, 2020 - karger.com
Abstract Using Richardson and Davidson's model and the sciences of pharmacokinetics and
clinical pharmacopsychology, this article reviewed the:(1) poor life expectancy associated …

Pneumonia risk, antipsychotic dosing, and anticholinergic burden in schizophrenia

JJ Luykx, CU Correll, P Manu, A Tanskanen… - JAMA …, 2024 - jamanetwork.com
Importance Antipsychotic drugs (particularly clozapine) have been associated with
pneumonia in observational studies. Despite studies of the associations between …

Placebo effects in randomized trials of pharmacological and neurostimulation interventions for mental disorders: An umbrella review

NTM Huneke, J Amin, DS Baldwin, A Bellato… - Molecular …, 2024 - nature.com
There is a growing literature exploring the placebo response within specific mental
disorders, but no overarching quantitative synthesis of this research has analyzed evidence …

[HTML][HTML] Adverse drug reactions and their fatal outcomes in clozapine patients in VigiBase: comparing the top four reporting countries (US, UK, Canada and Australia)

C De las Cuevas, EJ Sanz, J de Leon - Schizophrenia Research, 2024 - Elsevier
Background Pharmacovigilance findings and box warnings in the clozapine package inserts
have marked the history of clozapine. Objective This is the largest review of clozapine …