Engineering islets from stem cells for advanced therapies of diabetes
Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
Single-cell protein secretion detection and profiling
Secreted proteins play important roles in mediating various biological processes such as
cell–cell communication, differentiation, migration, and homeostasis at the population or …
cell–cell communication, differentiation, migration, and homeostasis at the population or …
Analyzing immune response to engineered hydrogels by hierarchical clustering of inflammatory cell subsets
Understanding the immune response to hydrogel implantation is critical for the design of
immunomodulatory biomaterials. To study the progression of inflammation around poly …
immunomodulatory biomaterials. To study the progression of inflammation around poly …
Spatiotemporal NF-κB dynamics encodes the position, amplitude, and duration of local immune inputs
Infected cells communicate through secreted signaling molecules like cytokines, which carry
information about pathogens. How differences in cytokine secretion affect inflammatory …
information about pathogens. How differences in cytokine secretion affect inflammatory …
Identification of druggable regulators of cell secretion via a kinome-wide screen and high-throughput immunomagnetic cell sorting
The identification of genetic regulators of cell secretions is challenging because it requires
the sorting of a large number of cells according to their secretion patterns. Here we report …
the sorting of a large number of cells according to their secretion patterns. Here we report …
A mineralizing pool of Gli1-expressing progenitors builds the tendon enthesis and demonstrates therapeutic potential
F Fang, Y ** secretome-mediated interaction between paired neuron–macrophage single cells
J Deng, Y Ji, F Zhu, L Liu, L Li, X Bai… - Proceedings of the …, 2022 - National Acad Sciences
Neuron-immune interaction through secreted factors contributes significantly to the complex
microenvironment in the central nervous system that could alter cell functionalities and fates …
microenvironment in the central nervous system that could alter cell functionalities and fates …
Spatial barcoding-enabled highly multiplexed immunoassay with digital microfluidics
H Li, X Liu, F Zhu, D Ma, C Miao, H Su, J Deng… - Biosensors and …, 2022 - Elsevier
Digital microfluidics (DMF), facilitating independent manipulation of microliter samples,
provides an ideal platform for immunoassay detection; however, suffering limited …
provides an ideal platform for immunoassay detection; however, suffering limited …
Multi‐Phenotypic Exosome Secretion Profiling Microfluidic Platform for Exploring Single‐Cell Heterogeneity
F Song, C Wang, C Wang, J Wang, Y Wu… - Small …, 2022 - Wiley Online Library
Cellular phenotypic and functional heterogeneities have advanced cancer evolution and
treatment resistance. Although exosome‐bound proteins reflect cellular functions, single …
treatment resistance. Although exosome‐bound proteins reflect cellular functions, single …
Deciphering Cell–Cell Interactions with Integrative Single‐Cell Secretion Profiling
L Li, H Su, Y Ji, F Zhu, J Deng, X Bai, H Li… - Advanced …, 2023 - Wiley Online Library
Cell–cell interactions are the fundamental behaviors to regulate cellular activities. A
comprehensive evaluation of intercellular interactions requires direct profiling of various …
comprehensive evaluation of intercellular interactions requires direct profiling of various …