Fluid shear stress sensing by the endothelial layer

E Roux, P Bougaran, P Dufourcq… - Frontiers in physiology, 2020 - frontiersin.org
Blood flow produces mechanical frictional forces, parallel to the blood flow exerted on the
endothelial wall of the vessel, the so-called wall shear stress (WSS). WSS sensing is …

A computational fluid dynamics modelling of maternal-fetal heat exchange and blood flow in the umbilical cord

D Kasiteropoulou, A Topalidou, S Downe - PLoS One, 2020 - journals.plos.org
Human fetal thermoregulation, maternal-fetal heat exchange, and the role of the umbilical
cord in these processes are not well understood. Ethical and technical limitations have …

Analysis of flow-induced transcriptional response and cell alignment of different sources of endothelial cells used in vascular tissue engineering

DM Rojas-González, A Babendreyer, A Ludwig… - Scientific Reports, 2023 - nature.com
Endothelialization of tissue-engineered vascular grafts has proven crucial for implant
functionality and thus clinical outcome, however, the choice of endothelial cells (ECs) is …

Nanoparticle localization in blood vessels: dependence on fluid shear stress, flow disturbances, and flow-induced changes in endothelial physiology

MJ Gomez-Garcia, AL Doiron, RRM Steele, HI Labouta… - Nanoscale, 2018 - pubs.rsc.org
Nanoparticles in the bloodstream are subjected to complex fluid forces as they move
through the curves and branches of healthy or tumor vasculature. While nanoparticles are …

Sinus hemodynamics variation with tilted transcatheter aortic valve deployments

H Hatoum, J Dollery, SM Lilly, JA Crestanello… - Annals of biomedical …, 2019 - Springer
Leaflet thrombosis is a complication associated with transcatheter aortic valve (TAV)
replacement (TAVR) correlated with sinus flow stasis. Sinus hemodynamics are important …

EndOxy: dynamic long-term evaluation of endothelialized gas exchange membranes for a biohybrid lung

S Klein, F Hesselmann, S Djeljadini, T Berger… - Annals of Biomedical …, 2020 - Springer
In the concept of a biohybrid lung, endothelial cells seeded on gas exchange membranes
form a non-thrombogenic an anti-inflammatory surface to overcome the lacking …

miR-342-5p downstream to Notch enhances arterialization of endothelial cells in response to shear stress by repressing MYC

X Zhang, J Sun, P Zhang, T Wen, R Wang… - … Therapy-Nucleic Acids, 2023 - cell.com
During vascular development, endothelial cells (ECs) undergo arterialization in response to
genetic programs and shear stress-triggered mechanotransduction, forming a stable …

[HTML][HTML] Advances in human placental biomechanics

RP Mayo - Computational and structural biotechnology journal, 2018 - Elsevier
Pregnancy complications are a major clinical concern due to the related maternal and fetal
morbidity. Many are caused through defective placentation, but research into placental …

Sinus hemodynamics in representative stenotic native bicuspid and tricuspid aortic valves: an in-vitro study

H Hatoum, LP Dasi - Fluids, 2018 - mdpi.com
(1) The study's objective is to assess sinus hemodynamics differences between stenotic
native bicuspid aortic valve (BAV) and native tricuspid aortic valve (TrAV) sinuses in order to …

Human fetal hearts with tetralogy of Fallot have altered fluid dynamics and forces

H Wiputra, CK Chen, E Talbi, GL Lim… - American Journal …, 2018 - journals.physiology.org
Studies have suggested the effect of blood flow forces in pathogenesis and progression of
some congenital heart malformations. It is therefore of interest to study the fluid mechanic …