Pancreatic adenocarcinoma (PDAC) is predicted to become the second leading cause of
cancer deaths by 2030 and this is mostly due to therapy failure. Limited treatment options …

Abstract Cancer-associated fibroblasts (CAFs), which are the most frequent stromal cells in
the tumor microenvironment (TME), play a key role in the metastasis of tumor cells …

Secreted autotaxin (ATX) promotes tumor progression by producing the pleiotropic lipid
mediator lysophosphatidic acid (LPA). In a recent Nature Cancer paper, Bhattacharyya et al …

Lysophosphatidic acid (LPA) is a phospholipid that displays potent signalling activities that
are regulated in both an autocrine and paracrine manner. It can be found both extra-and …

The TGFβ receptor inhibitor galunisertib showed promising efficacy in patients with
pancreatic ductal adenocarcinoma (PDAC) in the phase 2 H9H-MC-JBAJ study. Identifying …

Cancer is daunting pathology with remarkable breadth and scope, spanning genetics,
epigenetics, proteomics, metalobomics and cell biology. Cellular senescence represents a …

Autotaxin (ATX), encoded by ENPP2, is a clinical target in pancreatic ductal
adenocarcinoma (PDAC). ATX catalyzes the production of lysophosphatidic acid (LPA), an …

Cancer-associated fibroblasts (CAFs) are a heterogeneous population of non-malignant
cells that play a crucial role in the tumor microenvironment, increasingly recognized as key …

Background Although early-stage gastric cancer is a candidate for curative surgical
resection, the absence of specific early symptoms results in a late diagnosis and …

Lysophosphatidate (LPA)-mediated signaling is a vital component of physiological wound
healing, but the pathway is subverted to mediate chronic inflammatory signaling in many …